Could a blood pressure drug clear ICU brain fog?
NCT ID NCT04742673
First seen Feb 05, 2026 · Last updated Jun 22, 2026 · Updated 33 times
Summary
This study tested whether giving intravenous guanfacine to critically ill patients with delirium in the ICU could improve their brain function. 46 adults on breathing machines or for shock were randomly assigned to receive guanfacine or a placebo. Researchers measured days without delirium or coma, time off the ventilator, and cognitive test scores.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
-
Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Guanfacine (intravenous)
What this could lead to
If it works, this could point toward a treatment to reduce delirium and improve thinking in critically ill patients.
What could go wrong
This is a small, early-phase proof-of-concept study with only 46 participants. Results may not apply to all ICU patients, and the drug may cause side effects like low blood pressure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.