Could a blood pressure drug clear ICU brain fog?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. adult patients (≥ 18 years old) 2. requiring admission to an ICU 3. for treatment of respiratory failure (e.g., mechanical ventilation, non-invasive positive pressure ventilation \[NIPPV\], Extracorporeal Membrane Oxygenation \[ECMO\], optiflow) and/or for treatment of shock (e.g., vasopressors, ECMO, intra-aortic balloon pump \[IABP\]). Exclusion Criteria: 1. allergic to guanfacine, clonidine, or dexmedetomidine 2. on home antipsychotics who, therefore, require continuing antipsychotic administration in the hospital 3. present history of 2nd or 3rd degree heart block, or persistent bradycardia \< 50 beats/minute that requires intervention (e.g., atropine, glycopyrrolate). If patient has a pacemaker for bradyarrythmias, then patient does not meet this exclusion criterion and may be enrolled. 4. co-enrolled in another interventional trial examining similar outcomes or in a study that does not allow co-enrollment 5. expected death within 24 hours of enrollment or lack of commitment to aggressive treatment by family or the medical team (e.g., likely withdrawal of life support measures within 24 hours of screening) 6. acute or subacute neurologic deficit that is expected to make the patient incapable of living independently after hospital discharge due to cognitive deficits (e.g., stroke, intracranial hemorrhage, cranial trauma, intracranial malignancy, anoxic brain injury, cerebral edema). 7. dementia or other chronic neurologic disease or disorder that makes the patient incapable of living independently at baseline 8. active substance abuse, psychotic disorder, or homelessness without a secondary contact person (which would make long-term follow-up difficult) 9. blindness or deafness (which would prevent assessment of the study's outcomes) 10. pregnancy or breastfeeding 11. prisoner 12. inability to start informed consent process within 72 hours from the time that all inclusion criteria were met 13. Cardiac surgery within the current hospitalization.