Laser zaps prostate tissue: MRI reveals what happens next
NCT ID NCT01732991
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looked at 12 men with benign enlarged prostate who had Greenlight laser surgery. Researchers used MRI and special ultrasound scans to measure the area of dead tissue created by the laser and tracked urinary symptoms for a year. The goal was to better understand how the laser works, not to compare it with other treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Greenlight laser (prostatic photo-vaporization)
- What this could lead to
- If successful, this could help doctors better understand how laser treatment shrinks prostate tissue and improve surgical outcomes for men with enlarged prostate.
- What could go wrong
- This is a very small, early descriptive study with only 12 participants and no comparison group. It aims to measure tissue changes, not to prove the treatment works better than other options.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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12 people
The number who actually took part.
- Start date
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Sep 2012
- Finished
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Mar 2015
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Male participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient over 40 years old without an upper age limit * Informed orally and in writing, having signed a consent which match to the research * Patient with a benign prostatic hypertrophy requiring surgical treatment by PVP * Person affiliated to a social security system Exclusion Criteria: * Contraindications to MRI for patients with: * ocular metallic foreign object * any electronic medical device implanted by irremovable way (pacemakers, neuro-stimulator, cochlear implants ...) * metallic heart valve, old heart valves are specially an absolute contraindication because of risk of dysfunction * vascular clips implanted formerly on brain aneurysm * Allergy to Gadolinium * Contraindications to the contrast medium Sonovue: * Hypersensitivity to hexafluorinated sulphur or any other components of Sonovue * Recent acute coronary syndrome (within 6 months before the intervention) * Unstable ischemic heart disease (myocardial infarction being formed or evolving, typical angina of rest in the previous month) * Significant worsening of cardiac symptoms between the pre anaesthesia consultation and intervention * Recent intervention (less than 6 months) on coronary arteries or other factor suggesting clinical instability (changes in ECG, changes in clinical or biological parameters) * Acute heart failure or heart failure stage III or IV * Severe arrhythmias * Right-left shunt * Acute endocarditis * Valve prothesis * Severe pulmonary hypertension (pulmonary artery pressure \> 90mmHg) * Systemic hypertension uncontrolled * Respiratory distress syndrome * Prostatic biopsy \< 30 days or anal pathology * Patient with prostate cancer * Patient with a urinary infection * Patient with preoperative urinary catheter * Patient with a contraindication for surgery * Adult patient with a legal protection measure
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chru Tours
Tours, 37044, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.