Graphene oxide could revolutionize Kids' tooth fillings
NCT ID NCT07424053
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether graphene oxide can successfully treat decayed baby teeth that need pulp therapy. 126 children will be split into groups receiving graphene oxide, standard materials like MTA or zinc oxide, or a lesion sterilization technique. The goal is to see which approach works best for saving the teeth and reducing pain.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Graphene Oxide
- What this could lead to
- If successful, graphene oxide could become a new, effective option for treating decayed baby teeth, potentially improving outcomes and reducing procedure time.
- What could go wrong
- This is an early-stage trial with only 126 children, and graphene oxide has not been tested in this way before. It may not work better than existing treatments, and long-term safety is unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 126 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 to 10 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
\*Inclusion Criteria\* (First Arm) * Cooperative child * Presence of symptom-free deep carious lesions * Presence of at least two-thirds of the root length radiographically; restorable tooth (Second Arm) * Primary teeth diagnosed with pulp necrosis, root resorption equal to or less than one-third (with sufficient dental structure for absolute isolation with rubber dam) * History of spontaneous pain and mobility incompatible with chronological age, possibly with the presence of a sinus tract or swelling * Presence or absence of a radiolucent area in the periapical or furcation region \*Exclusion Criteria\* (First Arm) * History of systemic diseases * Teeth showing clinical and radiographical evidence of pulp degeneration, such as history of spontaneous or nocturnal pain, tenderness to percussion or palpation, pathologic mobility, swelling or fistulous tract, periodontal ligament (PDL) space widening, internal root resorption, external root resorption, furcal radiolucency/inter-radicular bone destruction, and/or periapical bone destruction * Teeth without a permanent successor * Teeth requiring more than 5 minutes to achieve hemostasis during the clinical procedure (Second Arm) * Children with a history of allergic reaction to the components of the tested materials * Children had used antibiotics in the last three months. * Teeth with pulp canal obliteration or internal or external pathological root resorption visible in periapical radiographs * Coronal destruction that would prevent absolute isolation with a rubber dam and/or restoration
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
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A doctor treating you
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