Grape seed extract shows promise for mild hypertension
NCT ID NCT06982365
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a grape seed extract supplement called Enovita can lower blood pressure in adults with elevated blood pressure or stage 1 hypertension. Eighty participants took either the supplement or a placebo twice daily for 8 weeks. Researchers measured changes in blood pressure, mood, stress, and inflammation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- grape seed extract (Enovita)
- What this could lead to
- If it works, this could offer a natural supplement option to help manage early high blood pressure.
- What could go wrong
- This is a small, short-term study (80 people, 8 weeks). Results may not apply to everyone, and supplements are not a substitute for prescribed medication.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
80 people
The number who actually took part.
- Started
-
Aug 2025
- Finished
-
Nov 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
30 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 30 to 65 years. * Diagnosed with Elevated Blood Pressure (systolic 120-129 mmHg and diastolic \<80 mmHg) or Stage 1 Hypertension (systolic 130-139 mmHg or diastolic 80-89 mmHg), according to American Heart Association guidelines. * No use of antihypertensive medication in the past 3 months. * Willing to comply with study procedures and follow-up visits. * Able to provide written informed consent. Exclusion Criteria: * Stage 2 Hypertension (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) at screening. * Chronic kidney disease (eGFR \< 60 mL/min/1.73 m²). * Diabetes mellitus (HbA1c ≥ 6.5%). * History of cardiovascular events (myocardial infarction, stroke) in the past 6 months. * Known allergy to grape products. * Current use of polyphenol supplements or similar herbal products. * Pregnancy or breastfeeding. * Participation in another clinical trial within the last 30 days.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Liaquat University of Medical & Health Sciences (LUMHS)
Jāmshoro, Sindh, 76090, Pakistan
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