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Grape seed extract shows promise for mild hypertension

NCT ID NCT06982365

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a grape seed extract supplement called Enovita can lower blood pressure in adults with elevated blood pressure or stage 1 hypertension. Eighty participants took either the supplement or a placebo twice daily for 8 weeks. Researchers measured changes in blood pressure, mood, stress, and inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
grape seed extract (Enovita)
What this could lead to
If it works, this could offer a natural supplement option to help manage early high blood pressure.
What could go wrong
This is a small, short-term study (80 people, 8 weeks). Results may not apply to everyone, and supplements are not a substitute for prescribed medication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Aug 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 30 to 65 years. * Diagnosed with Elevated Blood Pressure (systolic 120-129 mmHg and diastolic \<80 mmHg) or Stage 1 Hypertension (systolic 130-139 mmHg or diastolic 80-89 mmHg), according to American Heart Association guidelines. * No use of antihypertensive medication in the past 3 months. * Willing to comply with study procedures and follow-up visits. * Able to provide written informed consent. Exclusion Criteria: * Stage 2 Hypertension (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) at screening. * Chronic kidney disease (eGFR \< 60 mL/min/1.73 m²). * Diabetes mellitus (HbA1c ≥ 6.5%). * History of cardiovascular events (myocardial infarction, stroke) in the past 6 months. * Known allergy to grape products. * Current use of polyphenol supplements or similar herbal products. * Pregnancy or breastfeeding. * Participation in another clinical trial within the last 30 days.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Liaquat University of Medical & Health Sciences (LUMHS)

    Jāmshoro, Sindh, 76090, Pakistan

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Other studies related to the condition(s) this trial covers.