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Can a water pill get ICU patients home faster?

NCT ID NCT04180397

Disease control Sponsor: Morten H. Bestle Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a drug called furosemide (a water pill) can safely help intensive care patients who have too much fluid in their bodies. About 1000 adults will be randomly assigned to receive either furosemide or a placebo until the extra fluid is gone. The goal is to see if this treatment helps patients leave the hospital sooner and reduces complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2020

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: ALL below must be met. * Acute admission to the intensive care unit. * Age ≥ 18 years of age * Fluid overload ≥ 5% of ideal body weight. If possible, all fluids administered before admission to the intensive care unit are to be included in the calculation of cumulative fluid balance. * Clinical stable (minimum criteria: MAP \> 50 mmHg and maximum infusion of 20 microgram/kg/minute of noradrenaline and lactate \< 4.0 mmol/L) Exclusion Criteria: * Known allergy to furosemide or sulphonamides. * Known pre-hospitalization advanced chronic kidney disease (eGFR \< 30 mL/minute/1.73 m\^2 or chronic RRT). * Ongoing renal replacement therapy. * Anuria \> 6 hours. * Rhabdomyolysis with indication for forced diuresis * Ongoing life-threatening bleeding as these patients need specific fluid/blood product strategies. * Acute burn injury of more than 10% of the body surface area as these patients need a specific fluid strategy. * Severe dysnatremia (p-Na \< 120 or \> 155 mmol/L) as these patients need a specific fluid strategy. * Severe hepatic failure as per the clinical team. * Patients undergoing forced treatment. * Fertile women (women \< 50 years) with positive urine human chorionic gonadotropin (hCG) or plasma-hCG. * Consent not obtainable as per the model approved for the specific trial site.

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Conditions

The condition(s) this trial relates to.

Edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid overload

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    20 sites in 6 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Departement of Intensive Care, Gentofte Hospital

    TERMINATED

    Gentofte Municipality, Denmark

  • Departmen of Intensive Care

    RECRUITING

    Aalborg, 9000, Denmark

  • Department of Critical Care, University Medical Center Groningen

    RECRUITING

    Groningen, Netherlands

  • Department of Intensive Care

    RECRUITING

    Kolding, 6000, Denmark

  • Department of Intensive Care

    RECRUITING

    Odense, 5000, Denmark

  • Department of Intensive Care

    WITHDRAWN

    Vejle, 7100, Denmark

  • Department of Intensive Care

    TERMINATED

    Turku, Finland

  • Department of Intensive Care, Aarhus University Hospital

    TERMINATED

    Aarhus, Denmark

  • Department of Intensive Care, Herlev Hospital

    RECRUITING

    Herlev, 2730, Denmark

  • Department of Intensive Care, IKEM

    RECRUITING

    Prague, Czechia

  • Department of Intensive Care, Inselspital

    RECRUITING

    Bern, Switzerland

  • Department of Intensive Care, Landspitali National University Hospital of Iceland

    TERMINATED

    Reykjavik, Iceland

  • Department of Intensive Care, Liverpool Hospital

    RECRUITING

    Sydney, Australia

  • Department of Intensive Care, Nordsjællands hospital

    RECRUITING

    Hillerød, Denmark

  • Department of Intensive Care, Regionshospital Gødstrup

    RECRUITING

    Herning, 7400, Denmark

  • Department of Intensive Care, Regionshospital Nordjylland Hjørring

    RECRUITING

    Hjørring, Denmark

  • Department of Intensive Care, Regionshospitalet Randers

    RECRUITING

    Randers, 8930, Denmark

  • Department of Intensive Care, Rigshospitalet

    RECRUITING

    Copenhagen, 2100, Denmark

  • Department of Intensive Care, Royal North Shore Hospital

    RECRUITING

    Sydney, Australia

  • Department of Intensive Care, Stavanger University Hospital

    TERMINATED

    Stavanger, 4068, Norway

  • Department of Intensive Care, Sygehus Sønderjylland Aabenraa

    TERMINATED

    Aabenraa, Denmark

  • Department of Intensive Care, Tampere University Hospital

    TERMINATED

    Tampere, 33520, Finland

  • Department of Intensive Care, University Hospital Zealand, Roskilde

    RECRUITING

    Roskilde, Denmark

  • Department of Intensive Care, University Hospital of Ostrava

    NOT_YET_RECRUITING

    Ostrava, Czechia

  • Department of Intensive Care, University Hospital of Pilsen

    RECRUITING

    Pilsen, Czechia

  • Department of Intensive Care, Zealand University hospital

    RECRUITING

    Køge, 4600, Denmark

  • Department of Intensive Care, Ålesund Sjukehus

    TERMINATED

    Ålesund, Norway

  • Regionshospitalet Viborg

    RECRUITING

    Viborg, 8800, Denmark

  • Vilnius University Hospital Santaros Clinics

    RECRUITING

    Vilnius, Lithuania

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Other studies related to the condition(s) this trial covers.