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Scratching the surface: can tiny wounds spark new hair growth?

NCT ID NCT03491267

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tested if gentle wounding (using a laser or mild scraping) can trigger new hair growth in people with a type of scarring hair loss called CCCA. Researchers mapped bald spots on the scalp, applied different wounding methods with or without FDA-approved creams, and watched for new hairs using photos and small skin samples. The goal was to see if this approach could lead to new treatments for conditions where hair follicles are permanently lost.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

24 people

The number who actually took part.

Started

Jan 2018

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria Subjects who meet the following inclusion criteria will be included in the study: * Male or female older than 18 at the screening visit; * The subject is healthy, as determined by the investigator based on a medical evaluation including medical history; * The subject has clinical diagnosis of CCCA; * The subject's CCCA is of grades 2, 3 or 4, as assessed at the time of the screening visit. * The subject is willing and able to comply with the requirements of the protocol. In particular, subject must adhere to the visits schedule, concomitant therapy and hair processing prohibitions, subject instructions, and biopsy procedures; * The subject is willing to comply with the month long washout period if deemed necessary; * The subject has understood and signed an Informed Consent Form approved by the Institutional Review Board (IRB) prior to any investigational procedure Exclusion criteria Any subject who is meeting one or more of the following exclusion criteria at the screening visit and/or at the baseline visit will not be included in this study: * The subject has an underlying known disease, a surgical or medical condition that in the opinion of the investigator might put the subject at risk * The subject presents with any disease known or described to potentially interfere with a normal wound healing process * The subject is pregnant or breastfeeding at the time of enrollment or is planning to become pregnant at any point during the study period (by self report) * The subject has a past history of coagulation trouble * The subject has a past history of abnormal healing (hypertrophic scars/keloids within the past 10 years) * The subject has an underlying dermatological disease that in the opinion of the investigator could interfere with the study evaluations * The subject has scars, sunburn, either damaged or broken (cuts or abrasions) skin or other blemishes, or tattoos on the scalp in the treatment area * The subject is unwilling or unable to refrain from specific types of chemical hair styling and processing, including perms, straighteners, relaxers, dyes, weaves * The subject has a known allergy or sensitivity to any local anesthetic drug (e.g. lidocaine) or a local antiseptic planned to be used for the laser and/or biopsy procedures * The subject is in an exclusion period from a previous study or is participating in another clinical trial * The subject is an adult under guardianship or is hospitalized in a public or private institution, or is deprived of freedom * The subject is unable to communicate or cooperate with the Investigator due to language problems, poor mental development, or impaired cerebral function

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Johns Hopkins School of Medicine, Dermatology Department

    Baltimore, Maryland, 21287, United States

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Other studies related to the condition(s) this trial covers.