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Can blocking knee blood vessels ease arthritis pain?

NCT ID NCT07736248

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 30, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This trial tests whether a procedure called genicular artery embolization can reduce pain and improve function in people with knee osteoarthritis who have not responded to standard treatments. Doctors insert a thin tube into an artery in the groin, guide it to blood vessels around the knee, and inject tiny particles to block them. The study will measure changes in pain and quality of life over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a procedure called genicular artery embolization, where tiny particles are injected into blood vessels around the knee to block them
What this could lead to
If it works, this could offer a new, minimally invasive option for people with knee osteoarthritis who have not found relief from standard treatments.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. Risks include pain, bruising, or damage to blood vessels from the catheter.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Clinical diagnosis of knee osteoarthritis according to the criteria of the American College of Rheumatology. Radiographic evidence of osteoarthritis corresponding to Kellgren-Lawrence grades I-III. Moderate to severe knee pain for at least 6 months. Visual Analog Scale (VAS) score ≥5. 2. Failure of conservative treatment for at least 3 months including analgesics, non-steroidal anti-inflammatory drugs, physiotherapy, lifestyle modification, or intra-articular injections. Exclusion Criteria: 1. Kellgren-Lawrence grade IV osteoarthritis. 2. Previous knee arthroplasty. 3. Inflammatory arthropathies such as rheumatoid arthritis, psoriatic arthritis, or gout. 4. Active local or systemic infection. 5. Severe peripheral arterial disease. 6. Coagulation disorders. 7. Renal insufficiency (raised renal chemistry). 8. Pregnancy. 9. Known allergy to iodinated contrast media. 10. Refuse to provide written informed consent

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Angioembolization in knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.