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Gene tests could untangle the 150 names for bone and soft tissue tumors

NCT ID NCT07822204

Diagnosis Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Doctors name bone and soft tissue tumors mainly by how they look under a microscope, and more than 150 names are in use. The same tumor can get different names from different doctors. This study at Karolinska University Hospital in Stockholm asks whether reading the DNA, RNA, and chemical marks in tumor tissue can sort these tumors into clearer groups. Researchers compare the gene-based groups with the original diagnoses and with how participants fared over time. The study uses tissue already taken during regular care and does not change anyone's treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If gene-based grouping works better than microscope names, doctors could classify these tumors more consistently and match patients to the right care.
What could go wrong
This is an observational study using stored tissue, so it cannot prove that gene-based grouping improves patient outcomes. The findings may not apply to hospitals with different testing methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Mar 2046

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

People of any age with a tumor or tumor-like lesion of bone or soft tissue, benign, intermediate or malignant, diagnosed or reviewed at the Department of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden. The retrospective cohort is identified from the pathology archive by a predefined SNOMED-based search covering bone and soft tissue tumor codes, with an addendum capturing non- mesenchymal tumors that enter the differential diagnosis, such as melanoma, sarcomatoid carcinoma and lymphoma. The prospective cohort comprises people evaluated at the center during the study period. The center is a national referral center for sarcoma, so the population includes both locally diagnosed and referred cases.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histopathologically diagnosed tumor or tumor-like lesion of bone or soft tissue, including benign, intermediate and malignant lesions * Tissue sampled, resected or reviewed at the study center * Archived diagnostic material available and adequate for the analyses of the relevant cohort: formalin-fixed paraffin-embedded tissue, fresh-frozen tissue, or diagnostic glass slides * For the prospective cohort, documented informed consent Exclusion Criteria: * No retrievable diagnostic material or diagnostic report * Documented objection by the participant to the research use of their material or data

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Conditions

The condition(s) this trial relates to.

connective and soft tissue neoplasm sarcoma Soft Tissue Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone and soft tissue tumors

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Karolinska University Hospital

    RECRUITING

    Stockholm, 17176, Sweden

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