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New gene therapy trial offers hope for babies with rare muscle disease

NCT ID NCT07070999

First seen Dec 26, 2025 · Last updated May 23, 2026 · Updated 19 times

Summary

This study tests a single dose of a gene therapy called GB221 in babies aged 2 weeks to under 12 months who have spinal muscular atrophy (SMA) type 1, a severe muscle-weakening disease. The therapy delivers a working gene to help nerve cells control muscles. Researchers will check if it is safe and helps babies breathe and move better. The trial includes both babies who already have symptoms and those at risk but not yet showing signs.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hospital de Clínicas de Porto Alegre

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90035-903, Brazil

Conditions

Explore the condition pages connected to this study.