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Fructans under the microscope: can IBS patients tolerate this common food component?

NCT ID NCT04830410

Symptom relief Sponsor: Sahlgrenska University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether fructans, a type of carbohydrate found in foods like wheat, onion, and garlic, trigger symptoms in people with irritable bowel syndrome (IBS) with diarrhea. 65 participants followed a low FODMAP diet for 14 days, then reintroduced either fructan or placebo powder. Researchers measured symptom severity, gas production, and gut health to see if fructans cause problems and who might be more sensitive.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fructan powder
What this could lead to
If successful, this could help identify which IBS patients can safely add fructans back into their diet without triggering symptoms.
What could go wrong
This is a small, completed study with only 65 participants. Results may not apply to all IBS patients, and fructans may still cause symptoms in some individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Mar 2021

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * IBS according to ROME IV criteria (with diarrhoea) Exclusion Criteria: * Celiac disease or any other gastroenterology disease (such as inflammatory bowel disease, celiac disease, microscopic colitis, diverticulitis, radiation enteritis). * Suspected or known strictures, fistulas or physiological/mechanical GI obstruction, history of gastric bezoar. * Appendicectomy and cholecystectomy \<3 months. * Heart-, liver-, neurological-, or current psychiatric disease, diabetes, obesity (BMI\>30), other disease or surgery to the abdomen that affected intestinal function. * Implantable or portable electro-mechanical medical devices, e.g. pacemakers. * Swallowing disorders/dysphagia to food or pills. * Allergy or intolerances to foods. * Compliance to a special diet (including vegan, vegetarian, gluten-free or low FODMAP diet). * Pregnant or breast feeding. * Usage of antibiotics within 4 weeks prior to inclusion * Usage of alcohol more than 14 units per week. * No new pharmacological treatment during the study period. * Medications: laxatives, neuromodulators or opioids (morphine, codeine, tramadol…)

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Irritable bowel syndrome with diarrhea

Contacts and locations

Locations

  • Sahlgrenska University Hospital

    Gothenburg, Sweden

More trials for these conditions

Other studies related to the condition(s) this trial covers.