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Brain zaps + pill may ease twisted neck disorder

NCT ID NCT06328114

Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a personalized form of brain stimulation (TMS) combined with a medication can improve neck muscle control in people with cervical dystonia. Fifty adults with the condition will receive either real or sham TMS in a single day, along with the drug trihexyphenidyl. Researchers will use brain scans and movement sensors to measure changes over several months.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for cervical dystonia subjects: * 18yrs and older * Diagnosed with isolated cervical dystonia by Neurologist * Must be able to sign an informed consent * Must be literate Exclusion Criteria for cervical dystonia subjects: * Other neurological movement disorders diagnoses including other types of dystonia, Parkinsonism, or essential tremor * History of seizure disorder * Concomitant medications known to decrease seizure threshold * Illicit drug use * No TMS therapy for another indication within one month of this research study * Botulinum toxin injections within 3 months of the research study * Medications used for symptom treatment of dystonia including anticholinergic, benzodiazepines, and muscle relaxants among others within one month of the study * No physical or occupational therapy of the neck within one month of the study * Any contraindications to MRI or TMS Inclusion criteria for cervical dystonia subjects considering DBS * 18yrs and older * diagnosed with cervical dystonia by a Neurologist * must be able to sign informed consent * must be literate * On no medications or one medication to treat symptoms of dystonia for a minimum of one month prior to study participation Exclusion criteria for cervical dystonia subjects considering DBS * other neurological movement disorders diagnoses including Parkinsonism, or essential tremor * botulinum toxin injections within 3 months of research study * More than two medications used for symptom treatment of dystonia including anticholinergic, benzodiazepines, and muscle relaxants among others within one month of the study * contraindications to MRI or TMS * a history of seizures and anti-seizure medications by review of medical records

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Conditions

The condition(s) this trial relates to.

cervical dystonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Isolated cervical dystonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Duke University Health System

    Durham, North Carolina, 27705, United States

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Other studies related to the condition(s) this trial covers.