Can a simple varnish soothe sensitive teeth? new trial aims to find out
NCT ID NCT07286344
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two different fluoride varnishes to see which one better reduces tooth sensitivity in young adults. Participants receive a single application of either varnish, and researchers measure pain relief and quality of life improvements. The goal is to find a more effective way to manage dentin hypersensitivity.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- fluoride varnish
- What this could lead to
- If successful, this could point to a more effective fluoride varnish for treating tooth sensitivity, improving comfort and quality of life.
- What could go wrong
- This is a small, early-stage trial with only 92 participants, so results may not apply to everyone. The effect may be modest or temporary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 92 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Aug 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 40 years * Absence of systemic diseases with oral manifestations or requiring medications with antisialagogue effects * Fully dentate (excluding third molars or teeth extracted for orthodontic reasons) * Absence of periodontal disease, or periodontal condition in a stable state * Presence of at least one cervical lesion with a Schiff sensitivity score ≥ 1 * No previous treatment or restorative procedures on the target lesions (including no topical fluoride application within the last 6 months) Exclusion Criteria: * Patients requiring long-term use of NSAIDs or other analgesic/anti-inflammatory medications * Patients with allergy to milk proteins * Patients with allergy to organic resins or pine-derived substances * Pregnant or breastfeeding individuals * Patients with fixed orthodontic appliances in place
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Clinica de Rehabilitación Avanzada e Implantologia (CRAI)
RECRUITINGConcepción, Biobio, 4070420, Chile
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