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Hormone clues may predict severe febrile seizures

NCT ID NCT07463222

Knowledge-focused Sponsor: Aydin Adnan Menderes University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 120 children aged 6 months to 5 years who have a fever with or without a seizure. Researchers measure stress hormones (thyroxine, epinephrine, norepinephrine) right after a seizure and again when the child recovers. The goal is to see if these hormones are linked to how long the seizure lasts, if it happens again, and how long the child stays in the hospital. No treatments are tested—only observations are made to better understand febrile seizures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2026

An estimate. Start dates often move.

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population includes children aged 6 months to 5 years presenting with febrile seizures and an age-matched febrile control group without seizures, enrolled prospectively in a pediatric emergency department. The study evaluates differences in acute neuroendocrine hormone levels (thyroxine \[T4\], epinephrine, and norepinephrine) and their associations with seizure characteristics and short-term hospital outcomes.

Ages

6 months to 5 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children aged 6 months to 5 years presenting to the pediatric emergency department with fever (documented at presentation or reported by caregiver within the preceding 24 hours). * Case group: febrile seizure occurring in the context of a febrile illness. * Control group: febrile illness without seizure, selected to be age-matched to cases (e.g., within ±6 months). * Written informed consent obtained from a parent or legal guardian. Exclusion Criteria: * Suspected or confirmed central nervous system infection (e.g., meningitis, encephalitis). * Prior diagnosis of epilepsy or history of afebrile seizures. * Seizures attributable to acute metabolic derangements at presentation (e.g., significant hypoglycemia, clinically relevant electrolyte disturbances). * Known thyroid disease or use of thyroid hormone/antithyroid medications. * Known adrenal disorders or use of systemic catecholamine infusions at enrollment. * Major chronic neurologic disorders or acute head trauma. * Inability to obtain blood samples within protocol-defined time windows.

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Conditions

The condition(s) this trial relates to.

febrile seizures, familial Fever Seizures, Febrile

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Febrile convulsion Fever Neuroendocrine stress response

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aydin Adnan Menderes University Hospital

    Aydin, Aydın, 09010, Turkey (Türkiye)

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