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New study aims to unravel the mystery of fatigue in aging and Parkinson's

NCT ID NCT07485218

Knowledge-focused Sponsor: University of Applied Sciences and Arts of Southern Switzerland Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how tiredness affects daily life and muscle function in older adults (65+) and people with Parkinson's disease. Researchers will use questionnaires and simple exercises like handgrip and leg movements to measure fatigue. The goal is to better understand fatigue so doctors can improve care for these groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Three cohorts: 1. Nursing homes OA 40 residents in a nursing home of southern Switzerland will be recruited. The study will not affect any treatment. The key inclusion criteria for the participants' eligibility will be age greater than 80 years, modified Barthel Index score ≥85 points \[Tofani et al., 2019\] and ADL index score ≤12 points \[Katz et al., 1963\]. 2. Community-dwelling OA 40 active community-dwelling older people will be recruited. The key inclusion criterion for the participants' eligibility is an age comprised between 65 and 75 years. 3. 40 older outpatients with early phases of PD will be recruited. People with PD fulfilling the key inclusion and the following criterium are eligible for this study (see above): • Primary parkinsonism stages I-III of clinical disability, according to Hoehn and Yahr \[1967\].

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age greater than 65 years. Exclusion Criteria: * No understanding of the project language (Italian); * Moderate to severe dementia, with a Short Portable Mental Status Questionnaire (SPMSQ) score ≥1 \[Pfeiffer, 1975\] or Cognitive Performance Scale (CPS) ≥3 \[Morris et al., 1994\]; * Psychiatric disorders and moderate neurodegenerative diseases; * Delirium; * Persistent infections; * Inability to follow the study procedures (due to psychological disorders or dementia); * Severe hearing problem; * Unable or refuse to perform the physical tests (maximal handgrip strength, leg extension); * Severe cardiovascular and lung diseases (acute infection, heart, or lung failure, unstable angina and myocardial infarction during the previous month); * Renal failure, hepatic dysfunction; * Recent major surgery; * Severe cardiovascular exacerbations (RR \> 240/120, HR above the age predicted maximum of 220-Age); * Participation in another study with investigational drug within the 30 days preceding and during the present study; * Drug treatments that may interfere with the fatigue level; * Lifestyle factors and / or persistent addictions (drug or alcohol abuse).

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Conditions

The condition(s) this trial relates to.

Fatigue Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aged 65 years or older Parkinson disease (disorder)

Contacts and locations

Locations

  • Fondazione Opera Charitas

    Sonvico, Canton Ticino, 6968, Switzerland

  • Fondazione Parco San Rocco

    Morbio Inferiore, Canton Ticino, 6834, Switzerland

  • Multistruttura Sezione Anziani

    Bellinzona, Canton Ticino, 6500, Switzerland

  • Neuroimaging Research Unit, Division of Neuroscience San Raffaele Scientific Institute, Vita - Salute San Raffaele University

    Milan, MI, 20132, Italy

  • University of Applied Sciences and Arts of Southern Switzerland

    Manno, Canton Ticino, 6928, Switzerland

More trials for these conditions

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