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Cosmetic combo study seeks happier faces

NCT ID NCT06783621

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study tested how satisfied people were with their face and neck appearance after getting a combination of cosmetic treatments, including Botox, dermal fillers, a fat-reducing injection, a cooling device, and skincare products. It involved 130 participants with moderate to severe lines or contour concerns. The goal was to see if these treatments together improve satisfaction and psychological well-being.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
OnabotulinumtoxinA, JUVÉDERM products, KYBELLA, CoolSculpting Elite, and SkinMedica products
What this could lead to
If successful, this study could show that combining these cosmetic treatments improves satisfaction with face and neck appearance in diverse groups.
What could go wrong
This is a completed Phase 4 study, so results are already in. However, it is small (130 participants) and open-label, which may limit how broadly the findings apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

130 people

The number who actually took part.

Started

Jan 2025

Finished

Mar 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Applies to All Participants: * Must meet at least 1 of the following criteria for BOTOX UFL treatment per investigator's assessment: * Moderate or severe on Allergan Glabellar Line Severity Scale at maximum furrow * Moderate or severe on Forehead Line Severity Scale at maximum brow elevation and Moderate or Severe on Allergan Glabellar Line Severity Scale at maximum furrow * Moderate or severe on Lateral Canthal Line Severity Scale at maximum contraction (identical severity on both sides) * Must meet at least 3 of the following criteria for treatment in the face with at least 2 JUVÉDERM products, per investigator's assessment: * Moderate or severe on Allergan Loss of Jawline Definition Scale * Moderate or severe on Allergan Chin Retrusion Scale * Moderate, significant, or severe on Midface Volume Deficit Scale * Moderate or severe on Nasolabial Fold Severity Scale * Moderate or severe for both eyes on Allergan Infraorbital Hollows Scale * Minimal, mild, or moderate on 5-point Allergan Lip Fullness Scale * Moderate or severe on Allergan Cheek Smoothness Scale * Minimal, moderate, or severe on Allergan Temple Hollowing Scale Applies only to participants who will be treated for submental fullness: \- Moderate or severe on the Clinician-reported Submental Fat Rating Scale (for KYBELLA treatment) or Moderate, severe, or extreme (For CoolSculpting Elite treatment) per investigator's assessment. Exclusion Criteria: * History of medical condition that may put the subject at increased medical risk with exposure to OnabotulinumtoxinA, including diagnosed myasthenia gravis, Eaton-Lambert syndrome, amyotrophic lateral sclerosis, or any other condition that might interfere with neuromuscular function. * History of hypersensitivity or allergy to any botulinum toxin serotype, Streptococcal protein, lidocaine (or any amide-based anesthetics), HA products, any other excipients or constituents of the study drug, device, SkinMedica products and/or other products in the same class. * Marked facial asymmetry (e.g., asymmetry in eyebrow and/or eyelid position, asymmetrical smile or significant asymmetry in the lower face), facial nerve palsy, dermatochalasis, deep dermal scarring, excessively thick sebaceous skin, excessively photodamaged skin, or the inability to substantially lessen facial lines even by physically spreading them apart. * Previous plastic surgery, tissue grafting, permanent facial implants (e.g., polymethylmethacrylate, silicone, polytetrafluoroethylene), or tissue augmentation with silicone, fat, or other permanent dermal fillers of the face and/or neck or plan to undergo any of these procedures at any time during the study. * Prior exposure to botulinum toxin of any serotype to any part of the body within 6 months prior to screening. * Prior treatment with non-permanent soft tissue fillers or fat-reducing injectables in the face or neck within 12 months prior to screening. * Prior treatment with energy-based devices (e.g., intense pulsed light, Clear + Brilliant®, monopolar radiofrequency, microfocused ultrasound, etc.,) or other noninvasive fat reduction procedure and/or skin-tightening laser treatments in the face or neck within 6 months prior to screening.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Bellaire Dermatology Associates /ID# 270429

    Bellaire, Texas, 77401, United States

  • Boyd /Id# 270509

    Birmingham, Michigan, 48009-6301, United States

  • Center for Dermatology and Dermatologic Surgery /ID# 270390

    Washington D.C., District of Columbia, 20037-1495, United States

  • DelRicht Research - Prytania Street - New Orleans 308 /ID# 270425

    New Orleans, Louisiana, 70115, United States

  • Integrated Aesthetics /ID# 270399

    Spring, Texas, 77388, United States

  • Luxurgery /ID# 270430

    New York, New York, 10021, United States

  • Marcus Facial Plastic Surgery /ID# 270408

    Redondo Beach, California, 90277, United States

  • Pacific Clinical Innovations /ID# 270414

    Vista, California, 92083-6030, United States

  • Skin Research Institute LLC /ID# 270410

    Coral Gables, Florida, 33146-1837, United States

  • SkinDC /ID# 270411

    Arlington, Virginia, 22209, United States