Cosmetic combo study seeks happier faces
NCT ID NCT06783621
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study tested how satisfied people were with their face and neck appearance after getting a combination of cosmetic treatments, including Botox, dermal fillers, a fat-reducing injection, a cooling device, and skincare products. It involved 130 participants with moderate to severe lines or contour concerns. The goal was to see if these treatments together improve satisfaction and psychological well-being.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- OnabotulinumtoxinA, JUVÉDERM products, KYBELLA, CoolSculpting Elite, and SkinMedica products
- What this could lead to
- If successful, this study could show that combining these cosmetic treatments improves satisfaction with face and neck appearance in diverse groups.
- What could go wrong
- This is a completed Phase 4 study, so results are already in. However, it is small (130 participants) and open-label, which may limit how broadly the findings apply.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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130 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Mar 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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22 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Applies to All Participants: * Must meet at least 1 of the following criteria for BOTOX UFL treatment per investigator's assessment: * Moderate or severe on Allergan Glabellar Line Severity Scale at maximum furrow * Moderate or severe on Forehead Line Severity Scale at maximum brow elevation and Moderate or Severe on Allergan Glabellar Line Severity Scale at maximum furrow * Moderate or severe on Lateral Canthal Line Severity Scale at maximum contraction (identical severity on both sides) * Must meet at least 3 of the following criteria for treatment in the face with at least 2 JUVÉDERM products, per investigator's assessment: * Moderate or severe on Allergan Loss of Jawline Definition Scale * Moderate or severe on Allergan Chin Retrusion Scale * Moderate, significant, or severe on Midface Volume Deficit Scale * Moderate or severe on Nasolabial Fold Severity Scale * Moderate or severe for both eyes on Allergan Infraorbital Hollows Scale * Minimal, mild, or moderate on 5-point Allergan Lip Fullness Scale * Moderate or severe on Allergan Cheek Smoothness Scale * Minimal, moderate, or severe on Allergan Temple Hollowing Scale Applies only to participants who will be treated for submental fullness: \- Moderate or severe on the Clinician-reported Submental Fat Rating Scale (for KYBELLA treatment) or Moderate, severe, or extreme (For CoolSculpting Elite treatment) per investigator's assessment. Exclusion Criteria: * History of medical condition that may put the subject at increased medical risk with exposure to OnabotulinumtoxinA, including diagnosed myasthenia gravis, Eaton-Lambert syndrome, amyotrophic lateral sclerosis, or any other condition that might interfere with neuromuscular function. * History of hypersensitivity or allergy to any botulinum toxin serotype, Streptococcal protein, lidocaine (or any amide-based anesthetics), HA products, any other excipients or constituents of the study drug, device, SkinMedica products and/or other products in the same class. * Marked facial asymmetry (e.g., asymmetry in eyebrow and/or eyelid position, asymmetrical smile or significant asymmetry in the lower face), facial nerve palsy, dermatochalasis, deep dermal scarring, excessively thick sebaceous skin, excessively photodamaged skin, or the inability to substantially lessen facial lines even by physically spreading them apart. * Previous plastic surgery, tissue grafting, permanent facial implants (e.g., polymethylmethacrylate, silicone, polytetrafluoroethylene), or tissue augmentation with silicone, fat, or other permanent dermal fillers of the face and/or neck or plan to undergo any of these procedures at any time during the study. * Prior exposure to botulinum toxin of any serotype to any part of the body within 6 months prior to screening. * Prior treatment with non-permanent soft tissue fillers or fat-reducing injectables in the face or neck within 12 months prior to screening. * Prior treatment with energy-based devices (e.g., intense pulsed light, Clear + Brilliant®, monopolar radiofrequency, microfocused ultrasound, etc.,) or other noninvasive fat reduction procedure and/or skin-tightening laser treatments in the face or neck within 6 months prior to screening.
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Bellaire Dermatology Associates /ID# 270429
Bellaire, Texas, 77401, United States
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Boyd /Id# 270509
Birmingham, Michigan, 48009-6301, United States
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Center for Dermatology and Dermatologic Surgery /ID# 270390
Washington D.C., District of Columbia, 20037-1495, United States
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DelRicht Research - Prytania Street - New Orleans 308 /ID# 270425
New Orleans, Louisiana, 70115, United States
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Integrated Aesthetics /ID# 270399
Spring, Texas, 77388, United States
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Luxurgery /ID# 270430
New York, New York, 10021, United States
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Marcus Facial Plastic Surgery /ID# 270408
Redondo Beach, California, 90277, United States
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Pacific Clinical Innovations /ID# 270414
Vista, California, 92083-6030, United States
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Skin Research Institute LLC /ID# 270410
Coral Gables, Florida, 33146-1837, United States
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SkinDC /ID# 270411
Arlington, Virginia, 22209, United States