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New eye drug could slash injection frequency for wet AMD patients

NCT ID NCT06683742

Disease control Sponsor: EyePoint Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 6 times

Summary

This phase 3 trial tests EYP-1901, a new eye injection that may last longer than current treatments for wet age-related macular degeneration (AMD). About 400 participants will receive either EYP-1901 or the standard drug aflibercept. The goal is to see if EYP-1901 can maintain or improve vision while reducing the number of injections needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
EYP-1901 (a tyrosine kinase inhibitor given as an eye injection)
What this could lead to
If it works, this could mean fewer eye injections for people with wet AMD, making treatment easier and less burdensome.
What could go wrong
This is still an experimental drug; it may not work as well as the current standard treatment, and there could be side effects from the injection or the drug itself.
Why investors are watching

EyePoint Pharmaceuticals is running a phase 3 trial of EYP-1901, an injected drug for wet age-related macular degeneration, against the standard treatment aflibercept. For a small company, this late-stage readout is the main event: a positive result could support a regulatory submission, while a negative one would leave the company without a clear path forward.

If it works: If EYP-1901 matches aflibercept in controlling the disease, EyePoint could offer patients a longer-lasting treatment option and move toward approval. That outcome would validate the company's lead product and give it a commercial asset.

If it fails: Phase 3 trials often fail, and EYP-1901 could prove less effective or less safe than aflibercept. A failure or delay would likely force EyePoint to rethink its pipeline and could erode investor confidence.

AI-written from the trial record. Speculative, and not investment advice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit. * Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1). * For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit. Exclusion Criteria: * Subfoveal fibrosis, atrophy, or scarring in the center subfield. * BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.

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Conditions

The condition(s) this trial relates to.

wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

WAMD Wet age related macular degeneration

Contacts and locations

Locations

  • 3RP/ Windy City Retina

    Plainfield, Illinois, 60586, United States

  • AVRUC

    Carmel, Indiana, 46032, United States

  • Associated Retina Consultans

    Gilbert, Arizona, 85297, United States

  • Associated Retina Consultants - Phoenix

    Phoenix, Arizona, 85020, United States

  • Atlantis Eyecare

    Huntington Beach, California, 92647, United States

  • Austin Clinical Research LLC

    Austin, Texas, 78750, United States

  • Austin Research Center for Retina

    Austin, Texas, 45674, United States

  • Austin Retina Associates

    Austin, Texas, 78705, United States

  • Axon Clinical, s.r.o.

    Prague, Czechia

  • Bajcsy-Zsilinszky Korhaz es Rendelointezet

    Budapest, Hungary

  • Bay Area Retina Associates

    Walnut Creek, California, 94598, United States

  • Berkeley Eye Center

    Houston, Texas, 77027, United States

  • Black Hills Regional Eye Institute

    Rapid City, South Dakota, 45526, United States

  • Blue Ocean Clinical Research

    Clearwater, Florida, 33761, United States

  • Bnai Zion Medical Center

    Haifa, Israel

  • Budapest Retina Associates

    Budapest, Hungary

  • California Eye Specialists Medical Group, Inc.

    Redlands, California, 92373, United States

  • California Retina Consultants Oxnard Office

    Oxnard, California, 93036, United States

  • Carmel Medical Center

    Haifa, Israel

  • Cascade Medical Research lnstitute, LLC

    Springfield, Oregon, 97477, United States

  • Centro Brasileiro de Pesquisa Clinica - Blumenau

    Blumenau, Brazil

  • Centrum Diagnostyki i Mikrochirurgii Oka -LENS Sp. z o. o

    Olsztyn, Poland

  • Centrum Medyczne UNO-MED

    Tarnów, Poland

  • Clínica Oftalmológica São Lucas - Retina Clinic

    São Paulo, Brazil

  • Colorado Retina Associates

    Lakewood, Colorado, 80228, United States

  • Connecticut Eye Consultants, P.C.

    Danbury, Connecticut, 06810, United States

  • Cumberland Valley Retina Consultants

    Hagerstown, Maryland, 21740, United States

  • Debreceni Egyetem KK Szemklinika

    Debrecen, Hungary

  • Doctor Retina, PC

    Beverly Hills, California, 90211, United States

  • East Florida Eye Institute

    Stuart, Florida, 34994, United States

  • Envision Ocular, LLC

    Bloomfield, New Jersey, 07003, United States

  • Eye Center of Northern Colorado, PC

    Fort Collins, Colorado, 80528, United States

  • Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica

    Banská Bystrica, Slovakia

  • Fakultni nemocnice Kralovske Vinohrady

    Prague, Czechia

  • Fort Lauderdale Eye Institute

    Plantation, Florida, 33324, United States

  • Gailey Eye Clinic

    Bloomington, Illinois, 60616, United States

  • Ganglion Medical Center

    Pécs, Hungary

  • Global Research Management, Inc.

    Glendale, California, 91204, United States

  • Graystone Eye - Hickory Office

    Hickory, North Carolina, 28602, United States

  • Haik Humble Eye Center

    West Monroe, Louisiana, 71291, United States

  • Hospital Oftalmológico de Sorocaba (Centro de Estudos)

    Sorocaba, Brazil

  • Hospital de Olhos Oeste Paulista

    São Paulo, Brazil

  • Illinois Retina Associates, S.C.

    Oak Park, Illinois, 60304, United States

  • Imperial College Healthcare NHS Trust

    London, United Kingdom

  • K. B. Haji Bachooali Charitable Ophthalmic & E.N.T. Hospital

    Mumbai, India

  • Kaiser Permanente

    Oakland, California, 94611, United States

  • Kaplan Medical Center

    Rehovot, Israel

  • MedEye Associates

    South Miami, Florida, 33143, United States

  • Meir Medical Center Ophthalmology Department

    Kfar Saba, Israel

  • Mid Atlantic Retina

    Cherry Hill, New Jersey, 08034, United States

  • Mid Atlantic Retina Specialists

    Hagerstown, Maryland, 21740, United States

  • NC Retina Associates - Cary Research

    Cary, North Carolina, 27511, United States

  • NJ Retina

    Edison, New Jersey, 08820, United States

  • NYC Retina

    New York, New York, 45604, United States

  • Netralayam VIP

    Kolkata, India

  • Netrodaya - The Eye City

    Varanasi, India

  • North Carolina Retina Associates

    Wake Forest, North Carolina, 27587, United States

  • Northern California Retina Vitreous Associates Medical Group INC.

    Mountain View, California, 94040, United States

  • OFTALMIKA Sp. z o.o

    Bydgoszcz, Poland

  • Pacific Northwest Retina

    Bellevue, Washington, 98004, United States

  • Panhandle Eye Group, LLP. - Southwest Retina Specialists

    Amarillo, Texas, 79106, United States

  • Phoenix Retina Clinical Trials, LLC

    Phoenix, Arizona, 85050, United States

  • Piasta 47 Centrum Medyczne

    Warsaw, Poland

  • RCOC Clinical Research Institute Inc.

    Fullerton, California, 92835, United States

  • RSC Research, PLLC

    Denver, Colorado, 80210, United States

  • Rabin Medical Center

    Petah Tikva, Israel

  • Rand Eye Institute

    Deerfield Beach, Florida, 33064, United States

  • Retina Associates

    Elmhurst, Illinois, 60126, United States

  • Retina Associates New Orleans

    Metairie, Louisiana, 70006, United States

  • Retina Associates of Kentucky

    Lexington, Kentucky, 40509, United States

  • Retina Associates of Michigan

    Grand Blanc, Michigan, 48439, United States

  • Retina Associates of South Texas

    San Antonio, Texas, 78240, United States

  • Retina Associates of Western NY, PC

    Rochester, New York, 14620, United States

  • Retina Care Specialists

    Palm Beach Gardens, Florida, 45674, United States

  • Retina Consultants of Southern California

    Redlands, California, 92374, United States

  • Retina Consultants of Southern Colorado

    Colorado Springs, Colorado, 80909, United States

  • Retina Consultants of Texas

    Katy, Texas, 77494, United States

  • Retina Group of Florida

    Fort Lauderdale, Florida, 33308, United States

  • Retina Macula Institute of Arizona

    Scottsdale, Arizona, 85255, United States

  • Retina Prime at Jardim Europa Medical Center

    Aracaju, Brazil

  • Retina Specialists of Tampa

    Tampa, Florida, 33618, United States

  • Retina Vitreous Associates of Florida - Saint Petersburg

    St. Petersburg, Florida, 33711, United States

  • Retina Vitreous Center, PLLC

    Edmond, Oklahoma, 73013, United States

  • Retina Vitreous Surgeons of CNY, PC

    Liverpool, New York, 13088, United States

  • Retinal Consultants Medical Group

    Modesto, California, 95356, United States

  • Rising Retina Clinic

    Ahmedabad, India

  • Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie

    Lublin, Poland

  • Shamir Medical Center Ophthalmology Out Patient Clinic

    Be’er Ya‘aqov, Israel

  • Shanti Saroj Netralay

    Miraj, India

  • Shroff Eye Hospital

    Mumbai, India

  • SightSera Clinical Research LLC

    Greenwich, Connecticut, 06830, United States

  • South Coast Retina Center

    Long Beach, California, 90807, United States

  • St Elisabeth Krankenhaus

    Cologne, Germany

  • Star Vision Research

    Burleson, Texas, 76028, United States

  • Szpital sw. Rozy- obsolete; New Name: Szpital Św. Róży sp. z o.o.

    Krakow, Poland

  • TX RCTX Retina Consultants of Texas

    San Antonio, Texas, 78154, United States

  • Tennessee Retina

    Nashville, Tennessee, 37203, United States

  • Texas Retina Associates

    Arlington, Texas, 76012, United States

  • Texas Retina Associates

    Plano, Texas, 75075, United States

  • The Eye Care Institute

    Louisville, Kentucky, 40206, United States

  • The Eye Institute of West Florida

    Largo, Florida, 33770, United States

  • The Retina Partners

    Encino, California, 91436, United States

  • The Tel-Aviv Sourasky Medical Centre

    Tel Aviv, Israel

  • Tyler Retina Consultants

    Tyler, Texas, 75703, United States

  • VISUS, spol s.r.o.

    Náchod, Czechia

  • VRCNY/Long Island Vitreoretinal Consultants

    Westbury, New York, 11590, United States

  • VRMG Inc

    Sacramento, California, 95825, United States

  • Valley Retina Institute P.A.

    McAllen, Texas, 78503, United States

  • Virginia Retina Center

    Warrenton, Virginia, 20186, United States

  • Vitreo-Retinal Associates, PC

    Worcester, Massachusetts, 01605, United States

  • Warszawski Szpital Okulistyczny

    Warsaw, Poland

  • Wills Eye Physician Mid Atlantic Retina

    Bethlehem, Pennsylvania, 18017, United States

  • Win Retina

    Arcadia, California, 91006, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.