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New eye drug EYE103 aims to restore vision in macular degeneration and vein occlusion

NCT ID NCT07205887

Recruiting now Disease control Sponsor: EyeBiotech Ltd. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 25 times

Summary

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four weeks apart. The study measures changes in vision and retinal thickness over 12 weeks to see if the drug can improve outcomes.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Abilene, Texas

    RECRUITING

    Abilene, Texas, 79606, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Amarillo, Texas

    RECRUITING

    Amarillo, Texas, 79106, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Asheville, North Carolina

    RECRUITING

    Asheville, North Carolina, 28803, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Austin, TX

    RECRUITING

    Austin, Texas, 78705, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Austin, Texas

    RECRUITING

    Austin, Texas, 78705, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Bellaire, TX

    RECRUITING

    Bellaire, Texas, 77401, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Bellaire, Texas

    RECRUITING

    Bellaire, Texas, 77401, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Bloomfield, NJ

    RECRUITING

    Bloomfield, New Jersey, 07003, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Bloomfield, New Jersey

    RECRUITING

    Bloomfield, New Jersey, 07003, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Burleson, Texas

    RECRUITING

    Burleson, Texas, 76028, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Cary, North Carolina

    RECRUITING

    Cary, North Carolina, 27511, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dallas, TX

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Dallas, Texas

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Fort Lauderdale, FL

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Fort Lauderdale, Florida

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Germantown, Tennessee

    RECRUITING

    Germantown, Tennessee, 38138, United States

    Contact Email: •••••@•••••

  • Glendale, CA

    RECRUITING

    Glendale, California, 91204, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Glendale, California

    RECRUITING

    Glendale, California, 91204, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hagerstown, MD

    RECRUITING

    Hagerstown, Maryland, 21740, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hagerstown, Maryland

    RECRUITING

    Hagerstown, Maryland, 21740, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Knoxville, Tennessee

    RECRUITING

    Knoxville, Tennessee, 37922, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lemont, IL

    RECRUITING

    Lemont, Illinois, 60439, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Lemont, Illinois

    RECRUITING

    Lemont, Illinois, 60439, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Madison, MS

    RECRUITING

    Madison, Mississippi, 39110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Madison, Mississippi

    RECRUITING

    Madison, Mississippi, 39110, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Modesto, California

    RECRUITING

    Modesto, California, 95356, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mountain View, California

    RECRUITING

    Mountain View, California, 94040, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Nashville, TN

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Nashville, Tennessee

    RECRUITING

    Nashville, Tennessee, 37203, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Plano, Texas

    RECRUITING

    Plano, Texas, 75075, United States

    Contact Email: •••••@•••••

  • Round Rock, TX

    RECRUITING

    Round Rock, Texas, 78681, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Round Rock, Texas

    RECRUITING

    Round Rock, Texas, 78781, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sacramento, CA

    RECRUITING

    Sacramento, California, 95825, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sacramento, California

    RECRUITING

    Sacramento, California, 95841, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Sactamento, California

    RECRUITING

    Sacramento, California, 95825, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • San Antonio, TX

    RECRUITING

    San Antonio, Texas, 78240, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • San Antonio, Texas

    RECRUITING

    San Antonio, Texas, 78240, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • San Marcos, Texas

    RECRUITING

    San Marcos, Texas, 78666, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Santa Ana, California

    RECRUITING

    Santa Ana, California, 92705, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Scottsdale, AZ

    RECRUITING

    Scottsdale, Arizona, 85255, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Scottsdale, Arizona

    RECRUITING

    Scottsdale, Arizona, 85255, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Woodlands, TX

    RECRUITING

    The Woodlands, Texas, 77384, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • The Woodlands, Texas

    RECRUITING

    The Woodlands, Texas, 77384, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Wake Forest, NC

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Wake Forest, North Carolina

    RECRUITING

    Wake Forest, North Carolina, 27587, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • West Columbia, SC

    RECRUITING

    West Columbia, South Carolina, 29169, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • West Columbia, South Carolina

    RECRUITING

    West Columbia, South Carolina, 29169, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • West Jordan, Utah

    RECRUITING

    West Jordan, Utah, 84088, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Willow Park, Texas

    RECRUITING

    Willow Park, Texas, 76087, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

EYE103 (Restoret), a humanized antibody injected into the eye

What this could lead to

If successful, this could point toward a new treatment option for wet AMD and BRVO-related vision loss, potentially improving vision and reducing retinal swelling.

What could go wrong

This is an early Phase 2 trial with only 160 participants, so results may not apply to everyone. The drug is injected directly into the eye, which carries risks like infection or inflammation.

Conditions

The condition(s) this trial relates to.

retinal vein occlusion wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRANCH RETINAL VEIN OCCLUSION (BRVO) NEOVASCULAR AGE-RELATED MACULAR DEGENERATION (NVAMD)