Could a probiotic boost your memory and sleep?
NCT ID NCT06968299
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether a probiotic supplement called ExoBDNF can improve cognitive abilities like memory and concentration, as well as sleep and mood. About 50 adults aged 18 and older will take the supplement daily for 8 weeks. Researchers will measure changes using questionnaires and computer-based tests.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ExoBDNF probiotic supplement (Pediococcus acidilactici)
- What this could lead to
- If it works, this could point toward a simple, non-drug way to support memory, concentration, and sleep quality.
- What could go wrong
- This is a small, early-stage trial with no placebo group, so results may be due to chance or expectation. The supplement is not a treatment for any disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2025
- Expected to finish
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Dec 2025
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subjects must be volunteers who are 18 years of age or older, mentally clear and able to communicate. 2. Subjects who agree to participate in this trial and voluntarily sign the trial consent form. Exclusion Criteria: 1. Subjects who are expected to be or have been confirmed to be pregnant (medical history). 2. Subjects with gallbladder disease, gastrointestinal disease, gout, porphyria, or a history of gastric weight control surgery. 3. Subjects with high blood pressure (≥160/100 mmHg after resting for 10 minutes) or taking diuretics. 4. Subjects with heart disease, hepatorenal insufficiency, hyperthyroidism or hypothyroidism, Cushing's syndrome, malignant tumors, or any other disease that may affect the results of the study. 5. Subjects with severe hearing or visual impairment that makes it impossible to perform examinations and assessments. 6. Subjects with any history of brain surgery, penetrating, neurovascular, infectious or other severe brain injury, epilepsy or other major neurological abnormalities, such as traumatic brain injury with loss of consciousness for more than 24 hours, or memory loss after head trauma for more than 7 days were excluded. 7. Subjects with intellectual disabilities. 8. Subjects who had consumed probiotics or were expected to consume probiotics within 2 weeks before the screening visit. 9. Subjects who had participated in or were expected to participate in clinical trials within 4 weeks before the screening visit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Tri-Service General Hospital, National Defense Medical Center
RECRUITINGTaipei, Taiwan
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