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Exercise may lower blood pressure by reshaping gut microbes, study hints

NCT ID NCT03897777

Knowledge-focused Sponsor: North Carolina Agriculture & Technical State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how exercise affects gut bacteria and blood pressure in African Americans, who face higher rates of hypertension. Researchers will measure changes in blood pressure and gut microbes in 36 sedentary adults aged 30-50. The goal is to understand if exercise improves blood pressure by boosting helpful gut bacteria.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise training
What this could lead to
If successful, this could reveal how exercise improves blood pressure by changing gut bacteria, pointing toward better treatment strategies for hypertension in African Americans.
What could go wrong
This is a small, early-stage study (36 people) that is observational in nature. Results may not apply to everyone, and the link between exercise, gut bacteria, and blood pressure may be complex or indirect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 36 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2019

Expected to finish

Jun 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Sedentary (regular aerobic exercise frequency ≤2 times per week and duration ≤20 minutes per session; sedentary profession); * 30-50 years of age; * Control normotensive (systolic BP: 90-120 mmHg/diastolic BP: 60-80 mmHg) * Elevated to Stage 1 Hypertension (systolic BP: 120-129 mmHg/diastolic BP: 80-89 mmHg) and/or stage 1 hypertension (systolic BP: 130-159 mmHg/diastolic BP: 90-99 mmHg). Exclusion Criteria Diagnosed with any of the following: * Uncontrolled hypertension, stroke, history of heart attack, heart disease; * Metabolic disease (diabetes mellitus); * Inflammatory diseases (inflammatory bowel disease(s), rheumatoid arthritis, and systemic lupus erythematosus); * Kidney stones or gallbladder problems; * Kidney disease; * Liver disease; * Lung disease; * Cancer within the previous 6 months; (11) pregnant females; * Peripheral vascular disease; * Taking hypertension medications or those known to affect inflammation or metabolic function (anti-inflammatories, statins, thyroid medication) in the past 1 month; * Currently smoking; * Other conditions that would exclude vigorous exercise (\>2mV ST-segment depression or CVD signs and symptoms during the screening graded exercise test).

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Conditions

The condition(s) this trial relates to.

hypertensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypertension

Contacts and locations

Locations

  • North Carolina A&T State University

    Greensboro, North Carolina, 27411, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.