Can a simple exercise routine ease diabetic nerve damage?
NCT ID NCT07075367
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether a 12-week exercise program that works the trunk, hips, knees, and ankles can reduce symptoms and improve quality of life in people with diabetic peripheral neuropathy. Sixty-four adults with type 2 diabetes and nerve damage will be randomly assigned to either the full-leg program or a standard foot-and-ankle exercise routine. The goal is to see if the more comprehensive approach better eases nerve pain, improves balance, and reduces fear of falling.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- exercise program
- What this could lead to
- If it works, this could offer a simple, drug-free way to reduce nerve pain and improve balance and quality of life for people with diabetic neuropathy.
- What could go wrong
- This is a small, early-stage trial with only 64 participants. Exercise may not help everyone, and results may not apply to more active people or those with severe neuropathy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 64 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jan 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult individuals aged between 45 and 75 years, male or female, diagnosed with DM2; * DPN diagnosis based on vibration sensitivity tests assessed by a 128 Hz tuning fork and tactile sensitivity measured by a 10 g monofilament * Sedentary or irregularly active individuals (level A) according to the Physical Activity Level Classification - IPAQ * Score of at least 5 points on the Functional Independence Measure (FIM), i.e., requires supervision, but without physical contact * Absence of diabetic foot ulcer (DFU) for at least one month * No amputation or at most amputation of fingers, except for the hallux Exclusion Criteria: * Individuals involved in physical training programs simultaneously with the intervention * History of surgical intervention in the lower limbs or spine * Use of walking assistance devices * Diagnosis of severe cardiovascular disorder * Diagnosis of other neurological impairments in addition to DPN * Presence of dementia or inability to provide consistent information * Severe retinopathy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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