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Exercise may soothe chemo nerve pain, trial hopes

NCT ID NCT04888988

Symptom relief Sponsor: University of Rochester NCORP Research Base Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a structured exercise program can reduce chemotherapy-induced peripheral neuropathy (CIPN) — nerve damage causing pain, numbness, or tingling. About 133 cancer patients who received certain chemotherapies will either follow an exercise plan or receive standard care. The goal is to see if exercise improves symptoms better than usual treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
exercise program (EXCAP)
What this could lead to
If it works, this could offer a drug-free way to ease nerve pain and numbness caused by chemotherapy.
What could go wrong
This is a small, early-phase trial, so results may not apply to everyone. Exercise might not help all symptoms, and some patients may find it hard to stick with the program.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

133 people

The number who actually took part.

Started

Feb 2022

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of cancer * Have received neurotoxic chemotherapy within the past nine months (could still be on chemotherapy or have already completed chemotherapy; i.e., taxane-, platinum-, vinca alkaloid-, epothilone-, or proteasome inhibitor-based chemotherapy * Report one or more symptoms of CIPN at a level of \>= 4 on the CIPN symptom inventory on the Screening Form * Have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Have at least six months life expectancy * Be at least 18 years of age * Be able to read and understand English * Be able to provide written informed consent Exclusion Criteria: * Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking and progressive resistance exercise program, according to the participant's physician (e.g., oncologist, primary care) or physician's designee * Be identified as in the active or maintenance stage of exercise behavior per the Exercise Stages of Change Question on the Screening Form * Have planned surgery or radiation treatment during the course of the study (hormonal and biologic therapy is allowed) * Have contraindications for MRI scanning, per the MRI safety screening procedures of the MRI facility to be utilized for this participant * Are pregnant of have plans to become pregnant during the course of the study. Documentation of pregnancy and use of contraception can be obtained from the medical record. * Have a current or prior cancer in the central nervous system (spine, brainstem, brain) as this would interfere with assessments of brain functional connectivity.

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Conditions

The condition(s) this trial relates to.

cancer chemotherapy-induced neuropathy hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chemotherapy-induced peripheral neuropathy Hematopoietic and lymphoid cell neoplasm Malignant solid neoplasm

Contacts and locations

Locations

  • Abbott-Northwestern Hospital

    Minneapolis, Minnesota, 55407, United States

  • Beebe Health Campus

    Rehoboth Beach, Delaware, 19971, United States

  • Beebe South Coastal Health Campus

    Millville, Delaware, 19967, United States

  • Boulder Community Foothills Hospital

    Boulder, Colorado, 80303, United States

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois, 62269, United States

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois, 62526, United States

  • Carle Cancer Center

    Urbana, Illinois, 61801, United States

  • Carle at The Riverfront

    Danville, Illinois, 61832, United States

  • CaroMont Health - Lincoln Cancer Center

    Lincolnton, North Carolina, 28092, United States

  • CaroMont Regional Medical Center

    Gastonia, North Carolina, 28054, United States

  • Centralia Oncology Clinic

    Centralia, Illinois, 62801, United States

  • Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Chesapeake Regional Medical Center

    Chesapeake, Virginia, 23320, United States

  • Christiana Care - Union Hospital

    Elkton, Maryland, 21921, United States

  • Colorado Blood Cancer Institute

    Denver, Colorado, 80218, United States

  • Contra Costa Regional Medical Center

    Martinez, California, 94553-3156, United States

  • Corewell Health Grand Rapids Hospitals - Butterworth Hospital

    Grand Rapids, Michigan, 49503, United States

  • Crossroads Cancer Center

    Effingham, Illinois, 62401, United States

  • Decatur Memorial Hospital

    Decatur, Illinois, 62526, United States

  • Fairfield Medical Center

    Lancaster, Ohio, 43130, United States

  • FirstHealth of the Carolinas-Moore Regional Hospital

    Pinehurst, North Carolina, 28374, United States

  • Genesis Healthcare System Cancer Care Center

    Zanesville, Ohio, 43701, United States

  • Hawaii Cancer Care - Westridge

    ‘Aiea, Hawaii, 96701, United States

  • Hawaii Cancer Care Inc - Waterfront Plaza

    Honolulu, Hawaii, 96813, United States

  • Helen F Graham Cancer Center

    Newark, Delaware, 19713, United States

  • Kaiser Permanente Downtown Commons

    Sacramento, California, 95814, United States

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California, 95051, United States

  • Kaiser Permanente San Leandro

    San Leandro, California, 94577, United States

  • Kaiser Permanente-Fresno

    Fresno, California, 93720, United States

  • Kaiser Permanente-Roseville

    Roseville, California, 95661, United States

  • Kaiser Permanente-Santa Teresa-San Jose

    San Jose, California, 95119, United States

  • Kaiser Permanente-South Sacramento

    Sacramento, California, 95823, United States

  • Kaiser Permanente-South San Francisco

    South San Francisco, California, 94080, United States

  • Kaiser Permanente-Vallejo

    Vallejo, California, 94589, United States

  • Kaiser Permanente-Walnut Creek

    Walnut Creek, California, 94596, United States

  • Kaiser San Rafael-Gallinas

    San Rafael, California, 94903, United States

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii, 96826, United States

  • Lake Regional Hospital

    Osage Beach, Missouri, 65065, United States

  • Licking Memorial Hospital

    Newark, Ohio, 43055, United States

  • Marietta Memorial Hospital

    Marietta, Ohio, 45750, United States

  • MedStar Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • MedStar Washington Hospital Center

    Washington D.C., District of Columbia, 20010, United States

  • Medical Oncology Hematology Consultants PA

    Newark, Delaware, 19713, United States

  • Mercy Hospital

    Coon Rapids, Minnesota, 55433, United States

  • Mercy Medical Center - Des Moines

    Des Moines, Iowa, 50314, United States

  • Missouri Baptist Medical Center

    St Louis, Missouri, 63131, United States

  • Nash UNC HealthCare

    Rocky Mount, North Carolina, 27804, United States

  • Oncology Associates at Mercy Medical Center

    Cedar Rapids, Iowa, 52403, United States

  • Pali Momi Medical Center

    ‘Aiea, Hawaii, 96701, United States

  • Park Nicollet Clinic - Saint Louis Park

    Saint Louis Park, Minnesota, 55416, United States

  • Physicians' Clinic of Iowa PC

    Cedar Rapids, Iowa, 52402, United States

  • Prisma Health Cancer Institute - Butternut

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Easley

    Easley, South Carolina, 29640, United States

  • Prisma Health Cancer Institute - Eastside

    Greenville, South Carolina, 29615, United States

  • Prisma Health Cancer Institute - Faris

    Greenville, South Carolina, 29605, United States

  • Prisma Health Cancer Institute - Greer

    Greer, South Carolina, 29650, United States

  • Prisma Health Cancer Institute - Seneca

    Seneca, South Carolina, 29672, United States

  • Prisma Health Cancer Institute - Spartanburg

    Boiling Springs, South Carolina, 29316, United States

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Rice Memorial Hospital

    Willmar, Minnesota, 56201, United States

  • Ridgeview Medical Center

    Waconia, Minnesota, 55387, United States

  • Rocky Mountain Cancer Centers - Centennial

    Centennial, Colorado, 80112, United States

  • Rocky Mountain Cancer Centers - Swedish

    Englewood, Colorado, 80113, United States

  • Rocky Mountain Cancer Centers-Aurora

    Aurora, Colorado, 80012, United States

  • Rocky Mountain Cancer Centers-Boulder

    Boulder, Colorado, 80304, United States

  • Rocky Mountain Cancer Centers-Lakewood

    Lakewood, Colorado, 80228, United States

  • Rocky Mountain Cancer Centers-Littleton

    Littleton, Colorado, 80120, United States

  • Rocky Mountain Cancer Centers-Longmont

    Longmont, Colorado, 80501, United States

  • Rocky Mountain Cancer Centers-Midtown

    Denver, Colorado, 80218, United States

  • Rocky Mountain Cancer Centers-Rose

    Denver, Colorado, 80220, United States

  • Rocky Mountain Cancer Centers-Sky Ridge

    Lone Tree, Colorado, 80124, United States

  • Rocky Mountain Cancer Centers-Thornton

    Thornton, Colorado, 80260, United States

  • SIH Cancer Institute

    Carterville, Illinois, 62918, United States

  • Saint Rita's Medical Center

    Lima, Ohio, 45801, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    Green Bay, Wisconsin, 54303, United States

  • Saint Vincent Hospital Cancer Center at Sturgeon Bay

    Sturgeon Bay, Wisconsin, 54235-1495, United States

  • Southern Ohio Medical Center

    Portsmouth, Ohio, 45662, United States

  • Straub Clinic and Hospital

    Honolulu, Hawaii, 96813, United States

  • Strecker Cancer Center-Belpre

    Belpre, Ohio, 45714, United States

  • The Melanoma and Skin Cancer Institute

    Englewood, Colorado, 80113, United States

  • The Women's Imaging Center

    Denver, Colorado, 80209, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

    Chelsea, Michigan, 48118, United States

  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

    Ypsilanti, Michigan, 48197, United States

  • Trinity Health Medical Center - Brighton

    Brighton, Michigan, 48114, United States

  • Trinity Health Medical Center - Canton

    Canton, Michigan, 48188, United States

  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor

    Ann Arbor, Michigan, 48106, United States

  • Trinity Health Saint Mary Mercy Livonia Hospital

    Livonia, Michigan, 48154, United States

  • Unity Hospital

    Fridley, Minnesota, 55432, United States

  • University of Hawaii Cancer Center

    Honolulu, Hawaii, 96813, United States

  • University of Michigan Health - Sparrow Lansing

    Lansing, Michigan, 48912, United States

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