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Exercise may ease back pain by rewiring the brain, small study suggests

NCT ID NCT07480460

Symptom relief Sponsor: McGill University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether 14 weeks of supervised exercise (aerobic and resistance training) could reduce chronic low back pain in 57 adults. Researchers looked at changes in brain connectivity and immune-related gene activity to understand how exercise might relieve pain. The goal was to see if these biological changes explain why some people feel less pain after exercising.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
supervised physical exercise training
What this could lead to
If it works, this could point toward a non-drug treatment for chronic low back pain by showing how exercise changes the brain and immune system.
What could go wrong
This is a small, completed mechanistic study, not a large trial. Results may not apply to everyone with back pain, and exercise may not work for all types of pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

57 people

The number who actually took part.

Started

Mar 2017

Finished

Dec 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Chronic low back pain ≥ 3 months * Pain present at least half the days over the past 6 months * Average pain intensity ≥ 3/10 during week prior to enrollment Exclusion Criteria: * Diabetes * Neurological disorder * Psychiatric disorder * Significant cardiorespiratory disease * Under 18 years of age

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Conditions

The condition(s) this trial relates to.

Back Pain Chronic Pain Inflammation Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic low back pain (CLBP)

Contacts and locations

Locations

  • Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal

    Montreal, Quebec, H3W 1W4, Canada

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Other studies related to the condition(s) this trial covers.