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Exercise before and during radiotherapy: a new hope for rectal cancer?

NCT ID NCT06292975

Knowledge-focused Sponsor: University of Hull Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study planned to test if a 7-week program of aerobic and resistance exercise is feasible for people with locally advanced rectal cancer undergoing short-course radiotherapy. It aimed to recruit 30 patients and track how many joined, attended sessions, and stayed in the study. However, the trial was withdrawn before any participants were enrolled, so no data were collected.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
supervised vigorous aerobic interval exercise and unsupervised resistance exercise
What this could lead to
If this had succeeded, it could have shown that adding exercise to standard radiotherapy is practical and might improve treatment outcomes for rectal cancer patients.
What could go wrong
This trial was withdrawn before enrolling anyone, so no results exist. Even if it had run, it was a small, early feasibility study not designed to prove exercise improves cancer outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Started

Sep 2024

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years or older * Have been diagnosed with locally advanced rectal cancer using MRI (Magnetic Resonance Imaging) and histological finding, * Have been offered short-course neoadjuvant radiotherapy in the Queens Centre, Castle Hill Hospital * Willing and able to comply with all study requirements * Able and willing to voluntarily give informed consent to take part. Exclusion Criteria: * Inability to understand basic written and spoken English, as research materials will all be written in English. * Any movement deficiencies limiting ability to engage in exercise. * Impaired cognition and/or capacity limiting ability to provide informed consent. * Cardiovascular and/or cardiopulmonary conditions that will impede ability to safely perform exercise. * Severe psychiatric disorders. * With any other health condition which oncologists and research team agrees will impede ability to safely perform exercises. * Presence of metastatic cancer.

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Conditions

The condition(s) this trial relates to.

Motor Activity rectal cancer rectal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Locally advanced rectal carcinoma

Contacts and locations

Locations

  • Castle Hill Hospital

    Hull, East Yorkshire, HU16 5JQ, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.