Lung cancer patients try exercise during radiation: a feasibility test

NCT ID NCT07489391

Symptom relief Sponsor: University of Deusto Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a supervised exercise program is safe and doable for people with lung cancer who are undergoing radiation and chemotherapy. Ten participants will do aerobic, strength, and breathing exercises several times a week for 7-9 weeks. Researchers will track how well patients stick with the program and any side effects, to see if this approach is worth studying further.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: multimodal exercise program (aerobic, resistance, and breathing exercises)
What this could lead to: If successful, this could show that a tailored exercise program is safe and practical for lung cancer patients during treatment, potentially improving their physical function and well-being.
What could go wrong: This is a very small feasibility study with only 10 participants, so results may not apply to all patients. The main goal is to see if the program is possible, not to prove it works.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histological diagnosis of non-small cell lung cancer (NSCLC) at stage II-III (locally advanced), unresectable/inoperable. * Candidate for radical radiotherapy with concomitant chemotherapy, with or without maintenance Durvalumab. * ECOG performance status ≤2 (or Karnofsky index ≥60). * Ability to communicate adequately with the research team and to complete questionnaires and functional tests. * Signed written informed consent after receiving detailed information about the study. Exclusion Criteria: * Decompensated cardiorespiratory comorbidities that contraindicate moderate-intensity physical exercise: * New York Heart Association (NYHA) class III-IV congestive heart failure or unstable angina. * Recent myocardial infarction (\<6 months) or uncontrolled arrhythmias. * Very severe chronic obstructive pulmonary disease (COPD) GOLD IV with recent exacerbations, permanent home oxygen therapy, or severe pulmonary hypertension. * Severe physical or neurological limitations that prevent exercise. * Absolute medical contraindications to inspiratory muscle training: unresolved pneumothorax, recent thoracic surgery (\<4 weeks), or active hemoptysis. * Refusal or inability to understand/follow the program instructions (e.g., severe cognitive impairment, insurmountable language barrier).

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Conditions

The condition(s) this trial relates to.

lung neoplasm Motor Activity non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Non-small cell lung cancer Radiation therapy patient Stage II/III

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Lung cancer patients try exercise during radiation: a feasibility test

What the study statuses mean