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Exercise may alter Depression-Related brain chemicals, small trial hints

NCT ID NCT07062783

Knowledge-focused Sponsor: Kutahya Health Sciences University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests whether breathing exercises and aerobic exercise can change levels of certain brain and inflammation markers in people with major depression. Forty adults diagnosed with depression will do daily breathing and aerobic exercises for three weeks. Researchers will measure biomarkers linked to neuron health and inflammation to see if exercise has an effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
breathing exercises and aerobic exercise
What this could lead to
If successful, this could point toward exercise as a way to improve brain health and reduce inflammation in depression.
What could go wrong
This is a small, early-stage study measuring biomarkers, not clinical outcomes. Results may not lead to a treatment or apply to everyone with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Aug 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals who volunteer to participate in the study, * Between the ages of 18 and 40, * Have been diagnosed with clinical depression by a psychiatrist according to DSM-5 criteria Exclusion Criteria: * Individuals with chronic conditions accompanying depression, * Those with walking difficulties * Those with respiratory system disorders

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Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depression

Contacts and locations

Locations

  • Kutahya Health Sciences University

    Kütahya, Merkez, 43020, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.