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Scientists uncover how exercise fights diabetes at the molecular level

NCT ID NCT05572905

Knowledge-focused Sponsor: Lenka Rossmeislova Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how exercise changes certain fat molecules called PAHSAs, which help the body use insulin better. Researchers measured PAHSA levels in blood and fat tissue from 60 healthy people of different ages and body sizes before and after exercise. The goal was to understand the process behind exercise's insulin-sensitizing effects, which could lead to new treatments for metabolic disorders like type 2 diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

May 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * healthy young lean, young obese and older omnivorous men and women as defined by BMI, self-reported activity, self-reported medical history and self-reported diet assessment * must be able to withstand repeated blood draws * must be able to undergo abdominal fat biopsy Exclusion Criteria: * use of betablockers * use of glucocorticoids * use of non-steroidal anti-inflammatory drugs * use of metformin in prediabetes * use of psychiatric drugs such as selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, anticonvulsants and others * oncologic malignancy * chronic inflammatory or autoimmune diseases * diabetes mellitus * chronic ischemic heart disease * cardiovascular and pulmonary disease * renal and hepatological disease as assessed per biochemistry * musculo-skeletal deviations limiting physical performance * substance abuse * other than omnivorous diet

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Conditions

The condition(s) this trial relates to.

Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Insulin sensitivity

Contacts and locations

Locations

  • 3rd faculty of medicine, Charles University

    Prague, Prague, 10000, Czechia

More trials for these conditions

Other studies related to the condition(s) this trial covers.