Exercise study probes immune cell fuel use
NCT ID NCT07188389
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at how a single session of cycling exercise and overall fitness level affect the energy use of immune cells (CD8+ T cells and regulatory T cells) in healthy adults aged 20 to 40. Researchers measured changes in cell metabolism and function after moderate or heavy exercise. The goal was to understand basic biology, not to test a treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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102 people
The number who actually took part.
- Started
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Mar 2024
- Finished
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Apr 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men and women, aged 20-40 years * individuals presenting with average (40th-60th percentile) cardiorespiratory fitness (i.e., VO2max/VO2peak) for their age and sex will be included in acute exercise experiments; individuals with VO2max/VO2peak value \>20ml/kg/min will be included in cardiorespiratory fitness experiments * individuals categorized as 'low risk' for a cardiovascular event/heart disease when screened by American College of Sports Medicine (ACSM) criteria Exclusion Criteria: * adults under the age of 20 and over the age of 40 * Individuals with contraindications to exercise testing will be excluded * Individuals with musculoskeletal impairments preventing them from exercising on a cycle ergometer * Individuals with disease history known to impact the immune system and/or systemic metabolism will be excluded, including autoimmune diseases, HIV, Hepatitis, diabetes, cancer (completed treatment within \<6 months prior), hyper- or hypothyroidism * Pregnancy * Individuals using medications known to impact the cardiopulmonary and/or immune response to exercise with be excluded, including those using medication to control blood pressure (e.g., beta-blockers), daily steroidal and nonsteroidal anti-inflammatories (except daily aspirin), prescription allergy medication, ADHD medication (Ritalin or Adderall), thyroid medication (e.g., Levothyroxine), and chemotherapy (including treatments within the last 6 months). * Individuals habitually using tobacco products within the last 6 months or with excessive alcohol intake (\>10 drinks/week)
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Houston
Houston, Texas, 77204, United States
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