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New hope for chronic hives sufferers: experimental drug EVO756 under study

NCT ID NCT06873516

Symptom relief Sponsor: Evommune, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study tests an experimental drug called EVO756 in 160 adults with moderate to severe chronic spontaneous urticaria (CSU), also known as chronic hives. Participants must have had hives for at least 3 months and not gotten enough relief from standard antihistamines. The goal is to see if EVO756 can reduce itching and hives better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

182 people

The number who actually took part.

Started

Mar 2025

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Confirmed CSU diagnosis for at least 3 months with an inadequate response to H1-antihistamines. * Subjects who are taking H1-antihistamines must be on a stable regimen 4 weeks prior to Day 1 and while on study. * Urticaria Activity Score (UAS7) equal to or greater than 16 at Day 1. UAS entries must be completed for a minimum of 4 out of the 7 days prior to Day 1. Exclusion Criteria: * Any clinically significant abnormality in laboratory evaluations, physical examinations, vital signs, or ECG at Screening, according to the Investigator's discretion. * Use of certain medications. * History of diseases with urticaria or angioedema symptoms, other than CSU and symptomatic dermographism. * Significant medical history other than CSU, or any other condition which might interfere with the evaluation of CSU.

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Conditions

The condition(s) this trial relates to.

chronic idiopathic urticaria Chronic Urticaria urticaria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic spontaneous urticaria

Contacts and locations

Locations

  • AMR Fort Myers

    Fort Myers, Florida, 33912, United States

  • AMR Myrtle Beach

    Myrtle Beach, South Carolina, 29572, United States

  • AMR Utah

    Layton, Utah, 84041, United States

  • Advanced Clinical Research Institute

    Tampa, Florida, 33607, United States

  • Allergy Partners Clinical Research

    Asheville, North Carolina, 28803, United States

  • Allergy Research Canada

    Niagara Falls, Ontario, L2H 1H5, Canada

  • Allergy, Asthma, and Sinus Center

    Greenfield, Wisconsin, 53228, United States

  • Antelope Valley Clinical Trials

    Lancaster, California, 93534, United States

  • Austin Regional Clinic ARC Clinical Research

    Austin, Texas, 78726, United States

  • Bernstein Clinical Research Center

    Cincinnati, Ohio, 45236, United States

  • Bluegrass Allergy Care

    Lexington, Kentucky, 40509, United States

  • Boston Specialists

    Boston, Massachusetts, 02111, United States

  • Cahaba Dermatology Skin Health Center

    Birmingham, Alabama, 35244, United States

  • Center for Dermatology Clinical Research

    Fremont, California, 94538, United States

  • Centre de Recherche Saint-Louis

    Québec, Quebec, G1W 4R4, Canada

  • Centre de Recherche Saint-Louis - Montréal

    Montreal, Quebec, H1Y 3L1, Canada

  • DOCS Dermatology Research

    Canal Winchester, Ohio, 43110, United States

  • Dandelion Allergy Centre

    Mississauga, Ontario, L4W 5K3, Canada

  • DelRicht Research - Town Center Dermatology

    Wildwood, Missouri, 63040, United States

  • Delricht Research

    New Orleans, Louisiana, 70115, United States

  • Delricht Research - Lockhard Matter Dermatology

    Prosper, Texas, 75078, United States

  • Delricht Research - Priority Care

    Charlotte, North Carolina, 28205, United States

  • Delricht Research Louisiana

    Baton Rouge, Louisiana, 70809, United States

  • Delricht Research Louisville

    Louisville, Kentucky, 40205, United States

  • Delricht Research Smyrna

    Smyrna, Tennessee, 37167, United States

  • Dermatology and Ophthalmology Kume Clinic

    Sakai, Osaka, 5938324, Japan

  • FOMAT Medical Research

    Ventura, California, 93003, United States

  • Hutchinson Clinic

    Hutchinson, Kansas, 67502, United States

  • Ikebukuro Nishiguchi Fukurou Dermatology

    Toshima-ku, Tokyo, 1710021, Japan

  • Integrated Research of Inland

    Upland, California, 91786, United States

  • Johns Hopkins Bayview Medical Center

    Baltimore, Maryland, 21224, United States

  • MI Skin Innovations

    Northville, Michigan, 48167, United States

  • Medical Corporation Jitai-kai Tachikawa Dermatology Clinic

    Tachikawa, Tokyo, 1900023, Japan

  • Mita Dermatology

    Minato-Ku, Tokyo, 1080014, Japan

  • National Allergy and Asthma Research

    North Charleston, South Carolina, 29420, United States

  • NorthBay Clinical Research

    Santa Rosa, California, 95405, United States

  • Northridge Clinical Trials

    Northridge, California, 91325, United States

  • Optima Research Boardman

    Boardman, Ohio, 44512, United States

  • Osaka Medical and Pharmaceutical University Hospital

    Takatsuki, Osaka, 5698686, Japan

  • Piedmont Healthcare

    Statesville, North Carolina, 28625, United States

  • Red Maple Trials

    Ottawa, Ontario, K1H 1E4, Canada

  • Seattle Clinical Research Center

    Seattle, Washington, 98104, United States

  • Sneeze, Wheeze & Itch Associates LLC

    Normal, Illinois, 61761, United States

  • Studies in Dermatology

    Cypress, Texas, 77429, United States

  • The Indiana Clinical Trials Center

    Plainfield, Indiana, 46168, United States

  • The Iowa Clinic

    West Des Moines, Iowa, 50266, United States

  • ThinkPark Dermatology Clinic

    Shinagawa-Ku, Tokyo, 1416003, Japan

  • Toledo Institute of Clinical Research

    Toledo, Ohio, 43617, United States

  • Velocity Clinical Research, Lafayette

    Lafayette, Louisiana, 70508, United States

  • Velocity Clinical Research, Mobile

    Mobile, Alabama, 36608, United States

  • Vitality Clinical Trials

    Woodbury, New York, 11797, United States

  • Western Sky Medical Research

    El Paso, Texas, 79912, United States

  • Yoshikawa Skin Clinic

    Takatsuki, Osaka, 5690824, Japan

More trials for these conditions

Other studies related to the condition(s) this trial covers.