New hope for rare cholesterol disorder: drug may shrink artery plaque
NCT ID NCT07447648
First seen Mar 06, 2026 · Last updated May 21, 2026 · Updated 13 times
Summary
This study looks at whether adding the drug evinacumab to standard cholesterol-lowering treatment can reduce or slow the buildup of plaque in the heart arteries of people with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol from birth. About 52 participants will be followed for 18-24 months, using CT scans to measure plaque changes. The goal is to see if this stronger treatment lowers the risk of heart disease in this high-risk group.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Amsterdam University Medical Center, Amsterdam UMC, locatie AMC
RECRUITINGAmsterdam, Netherlands
Contact Email: •••••@•••••
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Centro per le Malattie Rare del Metabolismo dei Lipidi, Unità di Medicina Interna e Malattie Metaboliche, Dipartimento di Medicina Traslazionale e di Precisione Sapienza, Università di Roma
RECRUITINGRoma, Italy
Contact Email: •••••@•••••
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DAI di Medicina Clinica, Centro di Riferimento Regionale di Lipidologia e Dislipidemie, AOU Federico II di Napoli
RECRUITINGNaples, Italy
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Dipartimento Scienze-Cardiovascolari, AO "Sant'Anna e San Sebastiano" di Caserta
RECRUITINGCaserta, Italy
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Ege University,Director of Lipid and Prevention Clinic, Department of Cardiology
RECRUITINGBornova, Turkey (Türkiye)
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Erasmus University Medical Center, Dr. Molewaterplein 40
NOT_YET_RECRUITINGRotterdam, Netherlands
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Malattie Aterotrombotiche, Azienda Ospedaliero Universitaria Careggi
RECRUITINGFlorence, Italy
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Medicina Interna, Ospedale Molinette, AOU Città della Salute e della Scienza
NOT_YET_RECRUITINGTorino, Italy
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Nefrologia e Emodialisi, Centro Aterosclerosi e Dislipidemie, Ospedale Bassini, ASST Nord Milano
RECRUITINGCinisello Balsamo, Italy
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U.O. Astanteria/MCAU AOU, Policlinico "Paolo Giaccone" di Palermo
RECRUITINGPalermo, Italy
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U.O.C. di Medicina Interna, P.O. Nesima, ARNAS Garibaldi
NOT_YET_RECRUITINGCatania, Italy
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UOC Clinica Medica I, AOU di Padova
NOT_YET_RECRUITINGPadova, Italy
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Unité de Lipidologie et Prévention Cardiovasculaire, Centre de Compétence Dyslipidémies Rares (CEDRA), Service de Nutrition, Hôpital Pitié-Salpétriêre
NOT_YET_RECRUITINGParis, France
Contact Email: •••••@•••••
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Conditions
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