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Estrogen's role in muscle strength: a clue to preventing Age-Related muscle loss?

NCT ID NCT07649356

Knowledge-focused Sponsor: Mette Hansen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates how estrogen influences muscle growth and function in post-menopausal women during a 12-week exercise program. Researchers will measure changes in muscle mass, strength, and cellular health, focusing on muscle stem cells and mitochondria. The goal is to understand why muscle loss accelerates after menopause and find ways to counteract it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could point toward new strategies to prevent muscle loss in post-menopausal women.
What could go wrong
This is a small, early-stage observational study, so findings may not lead to direct treatments or apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will primarily be recruited from a radius of 50km from Aarhus. Participants recruited will be age matched to participants in the main trial.

Ages

47 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Regular menstrual bleeding (21-35 days cycle). * At least 9 menstrual cycles the last year * Age \>47 years old * BMI 20-30 Exclusion Criteria: * Only premenopausal women: Follicular stimulating hormone \> 30 mmol/L * Systematic strength training during the last year (\> 1 strength training session per week) * Systematic high intensity cardiovascular training during the last year (\<2 times per week) * Injuries to the legs which may prevent participation in the physical training program * Magnetizable metals or electrical devices implanted in the body, such as a pacemaker * Use of medication that can influence the effect of immobilization and/or training * Muscular or joint disorders which may affect the results * Metabolic diseases (such as diabetes and cardiovascular diseases) * Previous or present liver or cancer disease * Current or previous thrombosis * Porphyria * Epilepsia * Systemic autoimmune disease * Edema * Smoking or use of other nicotine containing products * Claustrophobia * Addictive behavior, defined as abuse of cannabis, opioids, or other intoxicating substances. * Lack of ability to cooperate * Blood parameters out of normal range at the health check * Blood pressure above 140/90 mmHg

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Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menopause Muscle mass and strength

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aarhus University

    RECRUITING

    Aarhus, 8000, Denmark

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