A simple swallow test might signal the perfect moment to remove a breathing tube
NCT ID NCT05574465
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This study tests whether a device that measures pressure in the esophagus can detect when a patient waking from anesthesia has regained the protective swallowing reflex needed to safely remove a breathing tube. Researchers will monitor patients aged 18 to 70 during their recovery from intubation, looking for a return of normal esophageal function. The goal is to find a more objective way to time extubation, potentially reducing the risk of aspiration and other complications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High-resolution solid state manometry device
- What this could lead to
- If successful, this could provide a precise, objective way to time the removal of breathing tubes, potentially reducing complications like aspiration.
- What could go wrong
- This is a small, early-stage study. The technique may not reliably predict safe extubation in all patients, and the device may be uncomfortable or difficult to use in this setting.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Expected to start
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Jul 2025
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients between 18 and 70 years of age (ASA I or II). * Already scheduled for endotracheal tube extubation. * Willing and able to give informed consent in either English or Spanish. Exclusion Criteria: * Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study. * Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data. * Patients not meeting entry criteria above. * Refusal to give informed consent. * Coagulopathy (INR \> 2 and/or platelet count \< 100,000. * White Blood Cell count \< 5,000/mm3 * Arrhythmia * Serum creatinine \> 2 mg/dl * Prior known or suspected nasal obstruction. * Known or suspected Zenker's diverticulum of esophagus, esophageal stricture, head/neck radiation therapy, hereditary telangiectasis, esophageal varices, cirrhosis. * Anticoagulant usage such as heparin or Plavix
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California, San Francisco
San Francisco, California, 94143, United States
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