New drug cocktail shows promise against esophageal cancer in early trial

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * No prior treatment for the condition. * Diagnosis of squamous cell carcinoma confirmed by endoscopic biopsy, with agreement to provide a pre-treatment tissue sample. * Patients must have thoracic esophageal cancer only. The primary site is determined by the center of the mass: 1. Upper thoracic esophagus: From the thoracic inlet to the lower border of the aortic arch, corresponding to 20-25 cm from the incisors by endoscopy. 2. Middle thoracic esophagus: From the lower border of the aortic arch to the level of the inferior pulmonary veins, corresponding to 25-30 cm from the incisors by endoscopy. 3. Lower thoracic esophagus: From the level of the inferior pulmonary veins to the stomach, including the gastroesophageal junction, corresponding to 30-40 cm from the incisors by endoscopy. * Deemed to have potentially resectable disease, with clinical stage III (cT3N1M0 to cT1-3N2M0) according to the UICC/AJCC TNM Staging System, 8th Edition. * Age ≥18 years and ≤75 years. * Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1. * Adequate organ function, meeting the following criteria (without transfusion or hematopoietic growth factor support within 14 days prior to the first dose): 1. Hematology: Absolute neutrophil count (ANC) ≥1.5 × 10⁹/L; Platelet count ≥100 × 10⁹/L; Hemoglobin ≥9.0 g/dL. 2. Biochemistry: Total bilirubin \<1.5 × upper limit of normal (ULN); Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \<2.5 × ULN; Serum creatinine ≤1.5 × ULN or calculated creatinine clearance ≥50 mL/min. 3. Coagulation: International normalized ratio (INR) ≤1.5; Activated partial thromboplastin time (APTT) ≤1.5 × ULN. * Male and female participants of childbearing potential must agree to use medically approved contraceptive methods during the study period and for 6 months after the last dose of the study drug(s). * The subject is capable of understanding, able to comply with study and follow-up procedures, and voluntarily signs a written informed consent form. Exclusion Criteria: * Disease assessed as unresectable based on imaging such as contrast-enhanced CT of the chest/abdomen, neck lymph node ultrasound, whole-body PET-CT scan (optional), or endobronchial ultrasound (EBUS) (optional). This includes: the presence of bulky lymph nodes (≥7 suspicious lymph nodes), multi-station lymph node involvement (≥2 stations of suspicious lymph nodes), or distant metastasis. * History of other malignancies (except for cervical carcinoma in situ or cured, localized basal cell carcinoma of the skin). * History of autoimmune diseases. * Recent or current use of corticosteroids or immunosuppressants. * History of severe hypersensitivity to antibody-based drugs. * History of chronic or recurrent autoimmune diseases. * History of interstitial lung disease, pulmonary fibrosis, diverticulitis, or systemic ulcerative gastritis. * Documented history of congestive heart failure, angina pectoris poorly controlled by medication; ECG-confirmed transmural myocardial infarction; uncontrolled hypertension; clinically significant valvular disease; high-risk or uncontrolled arrhythmias. * Severe systemic concurrent diseases, such as active infection or poorly controlled diabetic complications; coagulation disorders; bleeding tendency; or insufficient thrombolytic/anticoagulant therapy. * Female participants with a positive serum pregnancy test or who are breastfeeding, or individuals of childbearing potential unwilling to use contraception during the study period. * Active infection with HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), or positive HIV serology; or positive HBV DNA/HCV RNA. * Allergy to any of the drugs used in this study. * History of organ transplantation (including autologous bone marrow transplantation and peripheral stem cell transplantation). * History of peripheral nervous system disease, significant psychiatric disorder, or central nervous system disease. * Concurrent use of other anti-tumor drugs. * Current participation in, or prior participation in, another clinical trial that could potentially impact the results of this study.