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Can smarter epidural delivery ease labour pain better?

NCT ID NCT02278601

Symptom relief Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial tests three ways of delivering epidural pain relief during labour in first-time mothers. The goal is to see which method best prevents breakthrough pain—when the epidural wears off and extra pain relief is needed. The study also looks at whether better pain control could reduce the need for assisted deliveries like forceps or Caesarean sections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epidural delivery system using ropivacaine and fentanyl
What this could lead to
If successful, this could identify a better way to deliver epidural pain relief during labour, reducing breakthrough pain and potentially lowering the need for Caesarean or instrumental deliveries.
What could go wrong
The trial is large but results may vary among individuals. Epidural analgesia carries risks like low blood pressure or headache, and the best method may not prove superior for all outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

839 people

The number who actually took part.

Started

Jan 2015

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy (ASA physical status 1 and 2) nulliparous parturients at term (≥36 weeks gestation); 2. Singleton foetus 3. Early labour (cervical dilation ≤5cm) 4. Request labour epidural analgesia 5. At least 21 years of age Exclusion Criteria: 1. parturients with multiple pregnancies 2. non-cephalic foetal presentation 3. obstetric (e.g. pre-eclampsia, premature rupture of amniotic membranes, gestational diabetes on insulin) and uncontrolled medical (e.g. cardiac disease) complications 4. have contraindications to neuraxial blockade or have received parenteral opioids with the last 2 hours.

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Conditions

The condition(s) this trial relates to.

Breakthrough Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breakthrough pain

Contacts and locations

Locations

  • KK Women's and Children's Hospital

    Singapore, 229899, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.