New shot shows promise against tough lymphoma in japanese study

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Main Inclusion Criteria: • Must be at least 20 years of age, inclusive • Japanese participants • CD20 positivity at representative tumor biopsy 1. Part 1: * Diffuse large B-cell lymphoma (de novo or histologically transformed) * High-grade B-cell lymphoma * Primary mediastinal large B-cell lymphoma * Follicular lymphoma * Marginal zone lymphoma (nodal, extranodal of mucosa-associated lymphoid tissue, or splenic) * Small lymphocytic lymphoma 2. Part 2 : Arm 1: * Diffuse large B-cell lymphoma (de novo or histologically transformed) * Follicular lymphoma grade 1-3A * Relapsed or refractory disease and previously treated with at least 2 lines of systemic antineoplastic therapy including at least 1 anti-CD20 monoclonal antibody (mAb)-containing therapy. * Measurable disease by computed tomography (CT), magnetic resonance imaging (MRI) or positron emission tomography (PET)-CT scan Arm 2: • R/R FL grade 1, 2 or 3a, stage II, III, or IV, without evidence of transformation. * Previously treated with at least 1 prior anti-neoplastic agent, including anti-CD20 antibody * Must have a need for treatment initiation based on symptoms and/or disease burden (Groupe d'Etude des Lymphomes Folliculaires \[GELF\] criteria) * Eligible to receive R2 per investigator determination Arm 3: * One of following confirmed histologies (de novo or histologically transformed from FL or nodal marginal zone lymphoma) : o DLBCL, not otherwise specified (NOS) * "Double-hit" or "triple-hit" DLBCL * FL Grade 3B. * T-cell/histiocyte rich large B-cell lymphoma (LBCL) * International Prognostic Index (IPI) score ≥3 * No prior therapy for DLBCL or FL grade 3B (G3B) other than nodal biopsy, corticosteroids, or palliative radiotherapy. * Eligible to receive R-CHOP per investigator determination Arm 4: * One of following confirmed histologies (de novo or histologically transformed from FL or nodal marginal zone lymphoma) including: o DLBCL, NOS. o "Double-hit" or "triple-hit" DLBCL * FL Grade 3B. * T-cell/histiocyte rich LBCL * Relapsed or refractory to at least one prior therapy including at least one prior anti-CD20 antibody. * Either failed prior autologous hematopoietic stem cell transplantation (ASCT), or ineligible for autologous hematopoietic stem-cell transplantation (HSCT) * Eligible to receive GemOx per investigator determination Arm 5: • History of histologically confirmed CD20+ FL Grade 1-3a without evidence of transformation. • In CR or PR per Lugano criteria following first-line or second-line treatment with SOC regimen, including anti-CD20 antibody, and last dose of SOC within 6 months prior to enrollment Main Exclusion Criteria: • Primary central nervous system (CNS) lymphoma or CNS involvement by lymphoma at screening • Participants not eligible for high dose therapy with autologous hematopoietic stem cell transplantation due to personal choice, social issues, or similar • Known clinically significant cardiac disease • Chronic ongoing infectious diseases requiring treatment (excluding prophylactic treatment) Exclusion criteria for Part 2, Arms 2 through 5: Arm 2: • FL Grade 3b • Histologic evidence of transformation to an aggressive lymphoma * Contraindication to rituximab or lenalidomide * Unwilling or unable to take aspirin prophylaxis or prophylactic anticoagulant as clinically indicated Arm 3: • Contraindication to any of the individual drugs of the R-CHOP regimen Arm 4: * Contraindication to any of the individual drugs of the GemOx regimen Arm 5: * FL Grade 3b * Histologic evidence of transformation to an aggressive lymphoma