New drug combo aims to shrink lung tumors before surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Volunteer to participate and sign the informed consent form. 2. Age ≥ 18 years old, regardless of gender. 3. Histological and/or cytological diagnosis of resectable stage IIIA-IIIB (N2) NSCLC. 4. Measurable lesions based on the response evaluation criteria in solid tumors version 1.1（RECIST 1.1）. 5. Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1. 6. Subjects should provide tumor tissue for detection of PD-L1 expression level. 7. Sufficient organ and bone marrow function. 8. Expected survival ≥6 months. 9. The surgeon assessed that total lung function is able to withstand the proposed pneumonectomy procedure. Exclusion Criteria: 1. Tumor histologically or cytologically confirmed or combined with neuroendocrine carcinoma components, or sarcomatous/sarcomatoid lesions, or adenosquamous carcinoma, or special pathological types. 2. Previous treatment with another drug that targets T cell receptors (e.g. CTLA-4, OX-40, etc.); 3. Participants with known EGFR mutation or ALK translocation, and non-squamous cell carcinoma subjects need to identify EGFR and ALK mutation status; 4. Upper lung sulcus tumor or locally advanced unresectable or metastatic disease. 5. Previous anti-tumor therapy for the disease. 6. Subjects with known or suspected interstitial pneumonia.Radiation pneumonia or other moderate to severe lung disease that may interfere with the detection or management of drug-related pulmonary toxicity and seriously affect respiratory function. 7. Any serious active infection. 8. With uncontrolled or significant cardiovascular and cerebrovascular disease. 9. Active autoimmune disease requiring systemic treatment. 10. Immunosuppressant or systemic hormone therapy (dose \>10 mg/ day prednisone or other therapeutic hormone) for immunosuppression within 14 days prior to randomization.