Could a stomach pacemaker stop chronic nausea?
NCT ID NCT06464926
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 42 times
Summary
This study tests whether a device called the Enterra Therapy System (a stomach pacemaker) can reduce chronic nausea and vomiting in people whose stomach empties normally. About 148 adults with long-term, drug-resistant nausea will be enrolled. The device is surgically implanted and delivers mild electrical pulses to the stomach to try to improve symptoms and quality of life.
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This is a summary of
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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CHU de Bordeaux
RECRUITINGPessac, France
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CHU de Rouen
RECRUITINGRouen, 76031, France
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Cleveland Clinic Foundation
RECRUITINGCleveland, Ohio, 44195, United States
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Endeavor Health
RECRUITINGEvanston, Illinois, 60201, United States
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Functional Gut Clinic
RECRUITINGManchester, M3 4BG, United Kingdom
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Hackensack Meridian
RECRUITINGNeptune City, New Jersey, 07753, United States
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Hoag Hospital
RECRUITINGNewport Beach, California, 92663, United States
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Hôpital Edouard Herriot - CHU de Lyon
RECRUITINGLyon, 69003, France
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Hôpital Louis-Mourier
RECRUITINGColombes, France
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Indiana University Health
RECRUITINGIndianapolis, Indiana, 46202, United States
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Keck Medicine of USC
RECRUITINGLos Angeles, California, 90033, United States
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King's College Hospital NHS Foundation Trust
RECRUITINGLondon, SE5 9RS, United Kingdom
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Manchester University NHS Foundation Trust
RECRUITINGManchester, M23 9LT, United Kingdom
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Mayo Clinic Arizona
RECRUITINGScottsdale, Arizona, 85259, United States
Contact Email: •••••@•••••
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Sahlgrenska Universitetssjukhuset
RECRUITINGGothenburg, 413 45, Sweden
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Sutter Health
RECRUITINGSan Francisco, California, 94109, United States
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Temple Digestive Disease Center
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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UZ Leuven
RECRUITINGLeuven, Belgium
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University College London Hospital
RECRUITINGLondon, NW1 6DB, United Kingdom
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University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of South Florida
RECRUITINGTampa, Florida, 33606, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Enterra Therapy System (implantable gastric electrical stimulator)
What this could lead to
If it works, this could offer a new treatment option for people with chronic nausea and vomiting that hasn't responded to other therapies.
What could go wrong
This is a relatively small, early-stage trial (148 people) testing a surgical implant, which carries risks like infection or device malfunction. It may not work for everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.