Virus therapy takes on Hard-to-Treat cancers

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men and women aged 18-75 years inclusive; * Histologically confirmed diagnosis of a solid tumor; * Patients in whom surgical intervention is contraindicated; * Patients with exhausted methods of drug and radiation therapy; * General health status on the ECOG 0-2 scale; * Life expectancy of at least 3 months; * Acceptable indicators of a general blood test: hemoglobin ≥ 90 g/l; absolute number of neutrophils ≥ 1500/mm3; platelet count ≥ 100,000/mm3; * Glomerular filtration rate calculated according to the formula CKD-EPI\* ≥ 60 ml/min/1.73 m2; * Quick's prothrombin is more than 55%; * Acceptable indicators of liver function according to biochemical blood analysis: serum bilirubin \< 1.5 x ULN; AST \< 2.5 x ULN (or \< 5 x ULN in patients with liver metastases); ALT \< 2.5 x ULN (or \< 5 x ULN in patients with liver metastases); * Since the previous antitumor therapy (chemotherapy, targeted therapy, radiotherapy, immunotherapy) at least 30 days or at least 5 half-lives should elapse before the administration of the investigational drug; * Patients should recover from any previous surgery, radiotherapy, localized therapy, or systemic therapy to the 1st or lower degree of severity of adverse reactions (with the exception of alopecia or anemia, for which the 2nd degree of severity is allowed); * Women with preserved reproductive potential (who are not menopausal and have not undergone surgical sterilization) and men who are sexually active should use a reliable method of contraception (acceptable methods of contraception in this study are: intrauterine devices, oral contraceptives, contraceptive patch, long-acting injectable contraceptives, double barrier method (condom and spermicide, diaphragm and spermicide) during the study and at least 62 days after taking the last dose of the drug; * The ability to follow the procedures specified in the protocol during the entire study period; The patient's informed consent to participate in the clinical trial. Exclusion Criteria: * Withdrawal of consent to participate in the study.The development of severe or intolerable AES, which, in the researcher's opinion, make the patient's further participation in the study impossible. * Detection of HIV infection during the study; * According to the researcher, further participation in the study is not in the best interests of the patient. * There is a poor response to the study therapy, expressed by the progression of the disease in accordance with the criteria of RECIST 1.1 (RANO for neuroendocrine tumors) or worsening of clinical symptoms and / or laboratory * According to the researcher, the patient is not committed to the protocol requirements. * Deviations from the protocol, which, in the opinion of the sponsor or researcher, require the exclusion of the patient from the study.The onset of pregnancy; * The patient was included in the study with a violation of compliance with the inclusion/non-inclusion criteria. * Loss of contact with the patient for follow-up. * Death of the patient. * The decision of the sponsor or researcher for a reason not specified above.