Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

New pill helps sleep apnea patients stick with CPAP

NCT ID NCT05951023

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a safe sleep aid could help people with obstructive sleep apnea use their CPAP machine more each night. Many patients struggle to keep the mask on all night, often because they wake up easily. The trial gave a medication to raise the sleepers' arousal threshold, aiming to improve CPAP adherence. 42 adults with sleep apnea who had low CPAP use participated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

42 people

The number who actually took part.

Started

Aug 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ages 21-65 years old * Body Mass Index \<32 kg/m\^2 * Physician diagnosis of OSA (AHI ≥ 10) based on a clinical sleep study within the past 2 years (subjects who report a history of sleep apnea but do not have a sleep study report from the past 2 years available will be offered an overnight home sleep apnea test to verify OSA diagnosis) * AHI\>5/h on the overnight research sleep study #1 * Subject had the opportunity to use CPAP for at least 1 month * Continuous positive airway pressure (CPAP) data can be queried remotely and shows usage 0.5-4h/night (based on most recent 30 day period) * Interest to continue trying CPAP Exclusion Criteria: * "SAVE CPAP Side Effect Score" \>3 (1 point for each: dry mouth, nasal symptoms, CPAP pressure intolerance, claustrophobia, noise problems, soreness/skin irritation, mask fit/leak problems) * Any high-risk features: Epworth sleepiness score ≥18, safety-critical profession (e.g., commercial driver), prior sleep-related car accident, substantial hypoxemia during sleep \[SpO2\<70% for \>5min\] or awake \[SpO2\<92%\] * Any uncontrolled medical/psychiatric condition, or safety concern based on MD judgment * Pregnancy/Breastfeeding (current or planned during the next month) * Inability to complete study procedures, such as questionnaires that are only available/validated in English * Other known untreated sleep fragmenting disorder, such as periodic limb movement disorder, or narcolepsy * Unwilling or unable to withhold CPAP during polysomnography * Presence of tracheostomy * Hospitalization within the past 90 days * Allergy to the study drug * Regular use of opioids, or benzodiazepines * Chronically using study drug or other hypnotic * Significant circadian rhythm disorder or sleepwalking as an adult * Active illicit substance use or \>3 oz nightly alcohol use * Prisoners * Cognitive impairment, unable to provide consent, or unable to carry out research procedures * Safety concern based on MD judgment

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Obstructive sleep apnea are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • UC San Diego; Altman Clinical and Translational Research Institute Building

    La Jolla, California, 92121, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.