Tiny camera inside the gut could spot transplant complication faster
NCT ID NCT06247891
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested a special microscope-like camera (endocytoscopy) to diagnose upper gut graft-versus-host disease (aGVHD) in 14 patients who had a stem cell transplant. The camera was used during a standard endoscopy to see cells in real time. The goal was to see if this technique could spot aGVHD as well as the usual biopsy method.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could provide a faster, more accurate way to diagnose upper GI graft-versus-host disease without relying solely on biopsies.
- What could go wrong
- This is a very small pilot study with only 14 participants, so results may not apply to all patients. The technique is still experimental and not yet proven to replace standard biopsy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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14 people
The number who actually took part.
- Started
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Aug 2021
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients who underwent first allogeneic hematopoietic stem cell transplantation at Ruijin Hospital and developed persistent upper gastrointestinal symptoms after neutrophil engraftment were screened. Eligible participants were those with suspected upper gastrointestinal acute graft-versus-host disease whose symptoms did not resolve after at least 72 hours of supportive care and who underwent conventional endoscopy combined with endocytoscopy.
- Ages
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14 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * aged ≥ 14 years * developed UGI symptoms within first three months after engraftment or during the tapering of immunosuppressive agents Exclusion Criteria: * \< 14 year * with underlying gastrointestinal disease before allo-HSCT * incomplete medical information
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ye Zhao
Shanghai, 210000, China