New gene therapy aims to fix immune system in rare disease
NCT ID NCT06876363
First seen Nov 01, 2025 · Last updated May 23, 2026 · Updated 35 times
Summary
This study tests a new gene therapy called EN-374 for people with X-linked chronic granulomatous disease (X-CGD), a rare immune disorder that leads to severe infections. The treatment uses a modified virus to deliver a working gene to help the body produce infection-fighting cells. The trial enrolls 15 participants and focuses on safety and whether the therapy can restore normal neutrophil function.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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Columbia University Irving Medical Center, Morgan Stanley Children's Hospital
RECRUITINGNew York, New York, 10032, United States
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Duke University
RECRUITINGDurham, North Carolina, 27710, United States
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Johns Hopkins All Children's Hospital
RECRUITINGSt. Petersburg, Florida, 33701, United States
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University College London Hospital
RECRUITINGLondon, NW1 2PG, United Kingdom
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94158, United States
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55454, United States
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University of Utah, Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
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