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Zapping breathing muscles may help ventilator patients wean faster

NCT ID NCT07204821

Symptom relief Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether electrical stimulation of the muscles used to breathe in (inspiratory) versus out (expiratory) can help patients on mechanical ventilators wean off the machine faster. The trial will include 48 adults aged 45-65 who have been on a ventilator for at least 24 hours. Researchers will measure blood gases, diaphragm movement, and ICU stay length to compare the two stimulation approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Functional electrical stimulation device (Flexistem Digital electrical muscle stimulator)
What this could lead to
If it works, this could help patients on ventilators breathe on their own sooner, reducing ICU stays and complications.
What could go wrong
This is a small, early-stage trial with only 48 participants. The effect may be small or not apply to all patients. Electrical stimulation may cause discomfort or muscle fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All mechanically ventilated patients will be: * Their ages range from 45 to 65 years. * Their BMI is from 25-29.9kg/m2. * Mechanically ventilated for at least 24 hours. * They all have hypoxemic respiratory failure * Glasgow coma score (GCS) ranged from 6 to 12. * Richmond Agitation-Sedation Scale score: -2 to +2 * Patients and their relatives had written informed consent. Exclusion Criteria: * Hemodynamically unstable patients. * Patients with rib fractures. * Patients with implanted pacemaker. * Obese (BMI greater than 30 kgm2). * Tachycardia. * Uncontrolled hypertension. * History of neuromuscular disease at admission. * Spinal injuries. * Inability to trigger mechanical ventilation * Pregnancy * An anticipated stay on the ventilator \<72 h at the time of study * Patients who cannot attach electrodes due to local skin damage or infection * Patients with Severe intestinal gas accumulation, structural abnormalities, and other reasons that prevent ultrasound detection of diaphragm movement. * Congenital myopathies or neuropathies, and contraindications for expiratory muscle FES (cardiac pacemaker, refractory epilepsy, recent (\< 4 weeks) abdominal surgery). * Patients with unrelieved pneumothorax and restricted diaphragm movement disorders. * Chest or diaphragm malformation

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Conditions

The condition(s) this trial relates to.

respiratory failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ICU

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Beni-Suef University, Beni-Suef

    Cairo, Egypt

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