Mind over muscle: could perceived effort in exercise tame prediabetes?
NCT ID NCT06697756
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at whether doing resistance exercise with different levels of effort can improve blood sugar control in people with prediabetes. 48 adults aged 18 to 75 with prediabetes will be assigned to either high-effort or low-effort resistance training. Researchers will measure blood sugar levels and how well participants stick with the program.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- resistance exercise training with high or low effort
- What this could lead to
- If it works, this could show that adjusting exercise effort helps manage blood sugar in prediabetes, offering a simple way to reduce diabetes risk.
- What could go wrong
- This is a small, early-stage study with only 48 people. Results may not apply to everyone, and the effect on blood sugar might be small or unclear.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 48 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2024
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * age between 18 and 75 years; * presence of prediabetes (fasting glycemia between 100 and 125 mg/dL or glycated hemoglobin \[A1c\] between 5.7 and 6.4%). Exclusion Criteria: * Have a significant cognitive impairment, * Are non-ambulatory, * Have lower extremity amputation, * Have renal failure, * Have liver disease, * Have uncontrolled hypertension (\>160 mmHg systolic and/or \>100 mmHg diastolic), * Have unstable cardiovascular disease, * Have a history of severe cardiovascular problems, * Have decompensated heart failure, * Have uncontrolled arrhythmias, * Have severe pulmonary hypertension (mean pulmonary arterial pressure \>55 mm Hg), * Have severe and symptomatic aortic stenosis, * Have acute myocarditis, endocarditis, or pericarditis, * Have aortic dissection, * Have Marfan syndrome, * Have unrepaired aortic aneurysm, * Have proliferative diabetic retinopathy, * Have rapidly progressive terminal illness, * Are unable to perform resistance exercise to due preexisting musculoskeletal conditions (e.g., joint pain, chronic injury or tendinopathy), * Are under biguanide (metformin) treatment, but are taking for less than 3 months, * Have taken drugs known to increase the risk of tendon disorders (e.g., tendinopathy and tendon rupture) within the last 6 months. These drugs include, but may not be limited to: fluoroquinolones, glucocorticoids, aromatase inhibitors, anabolic steroids, antiretrovirals, isotretinoin, cephalexin, rituximab, sitagliptin, cephalosporins, azithromycin, and sulfonamides. * Are pregnant or trying to become pregnant during the study, * Are prisoners, * Are persons that require a legally authorized representative. Temporary exclusions include: * Being subjected to recent surgeries for which resistance training is not recommended, * Have symptomatic hernias, * Have acute illness, * Have recent fractures, or other injuries until resolved.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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UNM Exercise Physiology Lab
Albuquerque, New Mexico, 87131, United States
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