Tiny study hopes to Fine-Tune breathing machines for lung patients
NCT ID NCT07611409
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how changing the pressure inside a breathing machine affects lung function in 20 patients with obstructive airway diseases who are on full ventilator support. Researchers will test different pressure levels to see how they impact gas exchange and how the lungs empty. The goal is to find the best ventilator settings for these patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PEEP titration (adjusting ventilator pressure)
- What this could lead to
- If successful, this could help doctors set ventilators more precisely for patients with obstructive lung diseases, potentially improving breathing support.
- What could go wrong
- This is a very small, early physiological study with only 20 participants. It measures short-term effects, not long-term outcomes, so results may not apply broadly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Age \> 17 years. Invasive mechanical ventilation (endotracheal tube or tracheostomy) in controlled mode, with SpO2 \> 90%, for more than 12 hours. No contraindications for abdominal compression. AutoPEEP greater than 3 cmH2O measured during mechanical ventilation with full support and ZEEP. Full mechanical respiratory support, with no respiratory muscle activity (inspiratory or expiratory). \- Exclusion Criteria: Cardiovascular instability: Hypotension (MAP \< 60 mmHg), hypertension (SBP \> 180 mmHg), heart rate \< 40 bpm or \> 150 bpm. Refusal to participate in the study by a family member (without signed informed consent). Evidence of air leak: Pneumothorax, subcutaneous emphysema, pneumomediastinum. Intracranial hypertension (ICP \> 20 mmHg). Pregnant patient. Body Mass Index greater than 40 kg/m².
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Santojanni
Buenos Aires, Argentina