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Can eye drops beat abreva for cold sores? small study says maybe

NCT ID NCT04893577

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether EDTA eye drops can shorten cold sore outbreaks compared to the over-the-counter cream Abreva. Ten adults with a history of sun-triggered cold sores were randomly assigned to one of the two treatments. Researchers tracked how many days it took for each cold sore to heal completely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

10 people

The number who actually took part.

Started

Jan 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria To be eligible for enrollment, a subject must meet the following criteria: 1. Understands the requirements of the study and provides written informed consent prior to undergoing any study-related procedures. 2. Subject is a male or female between the ages of 18-65 years old, inclusive. 3. Fitzpatrick skin type II or III. 4. History of at least one year of herpes labialis induced by UV exposure. 5. Able to recall exact location of most common or most recent outbreak. 6. History of at least 50% of cold sore outbreaks occurring with UV (sun) exposure. 7. At least 1 HSV-1 outbreak within the past 12 months. 8. Experiences prodromal symptoms before HSV-1 outbreaks. 9. Subject is willing and able to comply with protocol-specified dosing, visits to the clinic and tracking of pain. Exclusion Criteria Subjects will be excluded from the study if they meet any of the following criteria: 1. Outbreak \<2 weeks prior to enrollment. 2. History of herpes simplex vaccine. 3. On antiviral suppression within the past 30 days. 4. Requires more than acetaminophen for pain from recurrent HSV outbreaks. 5. On any systemic or topical steroid, immune suppressant or chemotherapeutic agent within the past 30 days. 6. Use of tanning beds, history of sunburn, or beach vacation \<2 weeks prior to enrollment. 7. History of photosensitivity, lupus erythematosus, or current use of photosensitizing medication. 8. Current immunosuppressed state due to underlying disease (i.e. HIV infection) concomitant treatment (i.e. chemotherapy). 9. Current upper respiratory tract infection or any active illness that could trigger cold sores or affect overall health of the patient or the assessment of the study agent. 10. Pregnant or intending to become pregnant during the study. 11. Abnormal skin conditions in the area of the recurrent HSV1 outbreaks. 12. Enrolled in another clinical trial within the past 30 days. 13. Previously treated with EED. 14. On any analgesics or NSAIDs that cannot be stopped during the study. 15. Alcohol or drug abuse.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Utah MidValley Dermatology

    Murray, Utah, 84107, United States

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