Can eye drops beat abreva for cold sores? small study says maybe
NCT ID NCT04893577
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether EDTA eye drops can shorten cold sore outbreaks compared to the over-the-counter cream Abreva. Ten adults with a history of sun-triggered cold sores were randomly assigned to one of the two treatments. Researchers tracked how many days it took for each cold sore to heal completely.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
10 people
The number who actually took part.
- Started
-
Jan 2022
- Finished
-
Aug 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria To be eligible for enrollment, a subject must meet the following criteria: 1. Understands the requirements of the study and provides written informed consent prior to undergoing any study-related procedures. 2. Subject is a male or female between the ages of 18-65 years old, inclusive. 3. Fitzpatrick skin type II or III. 4. History of at least one year of herpes labialis induced by UV exposure. 5. Able to recall exact location of most common or most recent outbreak. 6. History of at least 50% of cold sore outbreaks occurring with UV (sun) exposure. 7. At least 1 HSV-1 outbreak within the past 12 months. 8. Experiences prodromal symptoms before HSV-1 outbreaks. 9. Subject is willing and able to comply with protocol-specified dosing, visits to the clinic and tracking of pain. Exclusion Criteria Subjects will be excluded from the study if they meet any of the following criteria: 1. Outbreak \<2 weeks prior to enrollment. 2. History of herpes simplex vaccine. 3. On antiviral suppression within the past 30 days. 4. Requires more than acetaminophen for pain from recurrent HSV outbreaks. 5. On any systemic or topical steroid, immune suppressant or chemotherapeutic agent within the past 30 days. 6. Use of tanning beds, history of sunburn, or beach vacation \<2 weeks prior to enrollment. 7. History of photosensitivity, lupus erythematosus, or current use of photosensitizing medication. 8. Current immunosuppressed state due to underlying disease (i.e. HIV infection) concomitant treatment (i.e. chemotherapy). 9. Current upper respiratory tract infection or any active illness that could trigger cold sores or affect overall health of the patient or the assessment of the study agent. 10. Pregnant or intending to become pregnant during the study. 11. Abnormal skin conditions in the area of the recurrent HSV1 outbreaks. 12. Enrolled in another clinical trial within the past 30 days. 13. Previously treated with EED. 14. On any analgesics or NSAIDs that cannot be stopped during the study. 15. Alcohol or drug abuse.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Herpes labialis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Utah MidValley Dermatology
Murray, Utah, 84107, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.