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Daily ECMO check: could a simple protocol save lives and money?

NCT ID NCT05486559

Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a daily, step-by-step assessment could help doctors safely remove patients from a life-support machine called ECMO sooner. 225 adults on ECMO were randomly assigned to either the daily protocol or usual care. The goal was to see if the protocol shortened the time on ECMO without increasing risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
daily assessment protocol for readiness to stop ECMO
What this could lead to
If successful, this protocol could help doctors safely remove patients from ECMO sooner, reducing complications and hospital costs.
What could go wrong
This is a completed trial, but the approach may not work for all patients or hospitals. The study is relatively small (225 people) and focused on one type of ECMO.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

225 people

The number who actually took part.

Started

Sep 2022

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient receiving VV-ECMO * Patient is located in a participating unit of an adult hospital Exclusion Criteria: * Patient is pregnant * Patient is a prisoner * Patient is \< 18 years old * Participant is receiving ECMO as bridge to transplant * Participant is receiving a hybrid configuration that includes an arterial cannula * Patient has received VV-ECMO for \> 48 hours

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extracorporeal membrane oxygenation complication

Contacts and locations

Locations

  • Baylor University Medical Center

    Dallas, Texas, 75246, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • Stanford University

    Stanford, California, 94305, United States

  • Texas Tech University Health Sciences Center of El Paso

    El Paso, Texas, 79905, United States

  • Toronto General Hospital

    Toronto, Ontario, M5G 2C4, Canada

  • UC San Diego Health

    San Diego, California, 92037, United States

  • University of Utah Health

    Salt Lake City, Utah, 84112, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

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