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Could a common virus and low vitamin d trigger MS? new study investigates

NCT ID NCT07256431

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nīmes Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study examined 110 people with radiologically isolated syndrome (RIS) — a condition where brain scans show signs that could lead to multiple sclerosis (MS). Researchers looked at whether past Epstein-Barr virus infection and low vitamin D levels are linked to a higher risk of developing MS. By analyzing blood samples, they hope to find better ways to predict who will go on to develop MS and who will not.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help identify who is at higher risk of developing multiple sclerosis, enabling earlier monitoring or treatment.
What could go wrong
This is an observational study that looks at past samples, so it cannot prove cause and effect. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

110 people

The number who actually took part.

Started

Aug 2023

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with RIS taken from ProBioRIS cohort (NCT06395662) plus healthy controls taken from the VDSS study (NCT05654818).

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * RIS patients from the ProBioRIS study with sufficient serum residuals for vitamin D testing and complete EBV serology. * Healthy subjects who participated in the VDSS trial and who provided consent for the use, for basic research purposes, of human biological samples collected during the trial. Exclusion Criteria: • Insufficient sample

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Conditions

The condition(s) this trial relates to.

Epstein-Barr virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epstein-Barr virus infections Radiologically isolated syndrome

Contacts and locations

Locations

  • CHU de Nîmes

    Nîmes, 30029, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.