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Glow-in-the-Mouth rinse could catch cavities before they start

NCT ID NCT07732127

Diagnosis Sponsor: Menoufia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This study tests whether a fluorescent starch nano-particle mouth rinse, combined with saliva biomarkers, can detect the earliest stages of tooth decay more accurately than a traditional visual exam. Sixty adults with at least one suspected early enamel lesion will be evaluated using both the new method and standard clinical inspection. The goal is to see if this approach can identify reversible damage before a cavity forms, enabling preventive care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Fluorescent Starch Nano-particles mouth rinse and salivary biomarker analysis
What this could lead to
If successful, this could offer a more sensitive, non-invasive way to catch tooth decay at a reversible stage, reducing the need for fillings.
What could go wrong
This is a small, early-stage diagnostic study. The new method may not prove more accurate than current visual exams, and lab-based salivary biomarkers may not be practical in routine dental visits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Presence of at least one suspected initial enamel carious lesion. Exclusion Criteria: * Cavitated carious lesions * Previous restorative treatment on the examined tooth * Antibiotic therapy during the previous month, * Systemic diseases affecting salivary secretion * Xerostomia or salivary gland disorders

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Conditions

The condition(s) this trial relates to.

enamel caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Initial caries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Menoufia Dental Hospital

    RECRUITING

    Shibīn al Kawm, Menoufia, Egypt