Could chemicals in our environment be causing earlier puberty in girls?
NCT ID NCT06083415
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at girls aged 6 to 8 who are showing early breast development. Researchers want to understand if chemicals in the environment, called endocrine disruptors, play a role. They will measure these chemicals in hair and blood, and also check body fat and growth. The goal is to see if simple environmental health measures can help slow or change this early development.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Environmental health measures
- What this could lead to
- If successful, this could help identify environmental triggers for early puberty and guide simple lifestyle changes to reduce risks.
- What could go wrong
- This is a small, early observational study, not a treatment trial. It may not prove cause and effect, and results may not apply to all girls.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 62 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
May 2023
- Expected to finish
-
May 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
6 to 8 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
For patients: Inclusion Criteria: * Girls aged 6 to 8 years * Presenting a breast development (isolated or not) * Undergoing scheduled pediatric day hospital care (HDJ) * Who agree to participate in the study * Whose parents agree to their child's participation in the study * French speaking * Whose parents speak French * Affiliated to social security Exclusion Criteria: * Organic brain causes of precocious puberty: History of neurocerebral disease (malformations, developmental abnormalities) * Organic causes of precocious puberty: Mac Cune Albright syndrome, ovarian cyst or tumor and adrenal hyperplasia * History of chemotherapy or radiation therapy * Presenting with a communication disorder * Pregnancy * Persons under protective measures * Persons deprived of liberty for judicial or administrative reasons For controls: Inclusion Criteria: * Girls aged 6 to 8 * Tanner stage 1: Absence of breasts and hairiness * Coming for routine consultation in the pediatric HDJ at Saint-Vincent-de-Paul hospital, or at the BLM practice in Lambersart, or to radiology for an MRI for another medical other medical reason * Agree to participate in the study * Whose parents agree to their child's participation in the the study * French-speaking * Whose parents speak French * Affiliated with social security Exclusion Criteria: * Signs of puberty (Tanner stages 2, 3, 4 and 5 for breast development) breast development) * Previous chemotherapy or radiotherapy * Presenting a communication disorder * Pregnant women * Persons under protective supervision * Persons deprived of their liberty for judicial or administrative reasons
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BREAST are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
2 sites. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Cabinet BLM
RECRUITINGLambersart, Hauts-de-France, 59130, France
-
Saint Vincent hospital
RECRUITINGLille, Hauts-de-France, 59000, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a text message save lives in a heat wave?
- 150,000 children to be tracked from birth to old age in massive health study
- Hidden in the gut: scientists hunt the everyday exposures behind Drug-Resistant bacteria
- Seeing the invisible: could live air quality displays spark healthier choices?
- Could a pollution-busting clinic ease children's breathing?
- Teaching Moms-to-Be about seafood safety: a new weapon against toxic exposures?