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Ear zaps could tame tummy troubles: scientists test Nerve-Stimulating device

NCT ID NCT04206540

Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a mild electrical current applied to the ear can activate the vagus nerve, which controls stomach function. Thirty healthy volunteers will receive ear stimulation and perform simple maneuvers like coughing. Researchers will measure nerve activity and stomach signals to see if this non-invasive approach could one day treat nausea and digestive disorders.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcutaneous Auricular Vagus Nerve Stimulation (device)
What this could lead to
If successful, this could help develop a non-invasive way to treat nausea, vomiting, and stomach disorders by stimulating the vagus nerve through the ear.
What could go wrong
This is a very early, small study in healthy people, not patients. It only measures nerve activity, not treatment effects, so it may not lead to any therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy volunteers 2. Aged 18-80 years 3. Willing to have electrodes placed in the external ear (ABVN arm) 4. Willing to perform vagal activity maneuver ( Vagal arm) Exclusion Criteria: 1. Unable to provide consent 2. Having gastric motility issues as determined by the PI or Sub I 3. Taking medications affecting gastric motility 4. Pregnant females 5. Prisoners

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy subjects

Contacts and locations

Locations

  • Indiana University Hosptial

    Indianapolis, Indiana, 46202, United States

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