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New combo may cut opioid use for cancer pain

NCT ID NCT05311774

Symptom relief Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding duloxetine (a nerve pain drug) to tramadol (a painkiller) can better control chronic cancer pain and reduce the amount of tramadol needed. 400 adults with cancer pain who had not taken painkillers before were split into two groups: one received duloxetine plus tramadol, the other a placebo plus tramadol. The goal was to see if the combination leads to lower tramadol use while still managing pain effectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

400 people

The number who actually took part.

Started

Apr 2022

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with cancer pain 1. age from 20-70 years old. 2. not receiving any type of analgesia before (opioid naïve, no adjuvants). Exclusion Criteria: 1. Difficult to be assessed for pain. 2. Any contraindication for duloxetine or tramadol.

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Conditions

The condition(s) this trial relates to.

Cancer Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer pain

Contacts and locations

Locations

  • Assiut University

    Asyut, 71111, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.